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Substance P(1⁻⁷) TFA

MCE 国际站：Substance P(1⁻⁷) TFA

品牌：MedChemExpress (MCE)

货号：HY-P1485A

CAS 号：2828433-22-1

生物活性： P(1⁻⁷)TFA物质是神经肽P物质(SP)的片段。当应用于孤束核时，P(1⁻⁷)TFA物质会产生降压和心动过缓作用[1]。

体内研究(In Vivo)：Substance P(1⁻⁷) is found to act as a very potent antagonist against the SP-induced responses and is formed locally in the nigra after SP injection. It is proposed that Substance P(1⁻⁷) is an endogenous modulator of SP actions[1]. Injection of low doses of Substance P(1⁻⁷) (1.0-4.0 pM simultaneously with SP or SP(5-11) (0.1 nM), reduce aversive behaviours induced by SP or SP(5- 11) significantly. These results indicate that SP(1⁻⁷) formed endogenously could modulate the actions of SP or SP(5-11) in the spinal cord[2]. MCE尚未独立确认这些方法的准确性。 仅供参考。

分子量：1014.06

Formula：C43H66F3N13O12

性状：固体

颜色：White to off-white

Sequence：Arg-Pro-Lys-Pro-Gln-Gln-Phe

Sequence Shortening：RPKPQQF

运输条件：美国大陆地区的室温；其他地区可能有所不同。

储存方式：密封储存，远离潮湿环境。粉末 -80°C 保存 2 年

Animal Administration [1][2]：Rats[1] Sprague-Dawley male rats weighing 250-300 g are anaesthetized with halothane and placed in a stereotaxic frame. An injection cannula, conically shaped with a penetration tip diameter of approximately 0.15 mm is loared into the SNR. Saline (0.2 µL), SP (0.007-0.7 nmol) or Substance P(1⁻⁷) (0.01-1 nmol) is injected into the left substantia nigra, pars reticulata (SNR) and the rat is placed in a rotometer. The substances are injected in a total volume of 0.2 µL over a period of 1 min. A group of animals is sacrificed by decapitation 1 hour after the injection, their brains are immediately removed and tissue samples are taken from left and right striatum, globus pallidum (GP) and substantia nigra (SN). Samples are assayed for SP and SP(1⁻⁷)[1]. Mice[2] The accumulated response time (s) of reciprocal movements of hindlimb scratching, biting, fore- and hindpaw licking are measured in Male mice (STD strain, 23-28 g) during the whole period of aversive response and 20 min at maximum. Substance P(1⁻⁷) is tested for its ability to inhibit the aversive response produced by intrathecal injection of SP or SP(5-11) (0.1 nM/mouse). Substance P (1⁻⁷) (1, 2, 4 pmol) is then administered together with SP or SP(5-11)[2]. MCE尚未独立确认这些方法的准确性。 仅供参考。

提供质量检测报告：Data Sheet、SDS、COA、RP-HPLC、MS、元素分析报告、产品使用指南

产品活性：Substance P(1⁻⁷) TFA 是神经肽 P 物质 (SP) 的片段。Substance P(1⁻⁷) TFA 可对孤束核产生抑制和缓和作用。

相关产品：SB-431542 | MRTX1133 | Ritanserin | SB-431542 | SB-431542 (Standard) | Substance P (1-9) | [Hyp3]-Bradykinin | PAR-4 Agonist Peptide, amide TFA | Ritanserin (Standard) | Delphinidin 3-rutinoside chloride | Calcimycin | Protease-Activated Receptor-4

热门产品线：抑制剂 | 稳定性同位素标记物 | 脂质 | 糖类

Trending products：Inhibitors | Isotope-Labeled Compounds | Lipids | Saccharides

参考文献：
[1]. Herrera-Marschitz M, et al. The substance P(1⁻⁷) fragment is a potent modulator of substance P actions in the brain. Brain Res. 1990 Jun 25;521(1-2):316-20.
[2]. Sakurada T, et al. Substance P(1⁻⁷) antagonizes substance P-induced aversive behaviour in mice. Neurosci Lett. 1988 Dec 19;95(1-3):281-5.