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LM22A-4

MCE 国际站：LM22A-4

品牌：MedChemExpress (MCE)

货号：HY-100673

CAS 号：37988-18-4

生物活性： LM22A-4 是酪氨酸激酶受体 B 的特异性激动剂，用于神经系统疾病研究。

体外研究(In Vitro)：LM22A-4 剂量依赖性上调 OPN 和 ALPase 的 mRNA 表达，5 µM 显著增加 OC mRNA 水平，并在时间依赖性范围内显著增加 OPN, ALPase 和 OC 的 mRNA 表达[2]。在用矿化培养基培养的 HCEM 细胞中，LM22A-4 促进 OPN 和 OC 的 mRNA 表达[2]。 MCE尚未独立确认这些方法的准确性。 仅供参考。

体内研究(In Vivo)：LM22A-4 (10 mg/kg, i.p.) 显著减少组织损伤程度和凋亡 (TUNEL 染色、半胱天冬酶-3 和 Bcl-2 表达)，与车辆处理组相比，显著改善肢体功能恢复。LM22A-4 (10 mg/kg) 处理导致神经元数量显著增加。LM22A-4 给药 (10 mg/kg) 显著改善神经学评分 [1]。 MCE尚未独立确认这些方法的准确性。 仅供参考。

分子量：339.34

Formula：C15H21N3O6

性状：固体

颜色：White to off-white

运输条件：美国大陆地区的室温；其他地区可能有所不同。

储存方式：粉末 -20°C 3年

Animal Administration [1]：ICR mice are randomly divided into five groups: sham treatment, spinal cord injury, spinal cord injury combined with solvent treatment, spinal cord injury combined with LM22A-4 treatment (10 mg/kg), and spinal cord injury combined with LM22A-4 treatment (15 mg/kg), with each group containing 26 animals. Preparation of the mouse SCI model is based on a previous study and on a protocol employed by this group. Briefly, a mouse is anesthetized via the administration of chloral hydrate (4 mg/kg) before a 3-cm incision is introduced on its back. T7-T11 vertebrae are exposed under a surgical microscope before the laminae are removed with a vascular clip to fully expose the spinal cord. The spinal cord is clamped with the vascular clip for 1 minute with a force of 10 g. The animal is then subjected to complete staunching of the bleeding, and the incised dorsal muscle and skin are sutured. Mice from the control group undergo laminectomy, full exposure of the spinal cord, and subsequent suturing, but without aortic clamping. After the surgery, the mice are placed on a warm blanket until fully awake and are then housed in cages accommodating a normal diet. After the SCI treatment, 14 mice are sacrificed to enable molecular and histological examinations; the other 14 mice are allowed to live for 20 days for neurological scoring and are sacrificed on day 20 via cervical dislocation. MCE尚未独立确认这些方法的准确性。 仅供参考。

提供质量检测报告：Data Sheet、SDS、COA、HNMR、RP-HPLC、MS、产品使用指南

产品活性：LM22A-4 是一种特异性的 tyrosine kinase receptor B 激动剂，常用于神经系统疾病研究。

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参考文献：
[1]. Yu G, et al. Protective effects of LM22A-4 on injured spinal cord nerves. Int J Clin Exp Pathol. 2015 Jun 1;8(6):6526-32. eCollection 2015.
[2]. Kajiya M, et al. BDNF mimetic compound LM22A-4 regulates cementoblast differentiation via the TrkB-ERK/Akt signaling cascade. Int Immunopharmacol. 2014 Apr;19(2):245-52