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ICI 153110

MCE 国际站：ICI 153110

品牌：MedChemExpress (MCE)

货号：HY-100239

CAS 号：87164-90⁻⁷

生物活性：ICI 153110 是一种口服有效的磷酸二酯酶抑制剂，具有血管扩张和正性肌力作用，旨在治疗充血性心力衰竭。

体内研究(In Vivo)：ICI 153110 is an orally active phosphodiesterase inhibitor with both vasodilating and inotropic properties which is designed for the treatment of congestive cardiac failure. Fourteen animals have died as a direct or indirect consequence of ICI 153110 administration in the high-dose main test and reversibility groups. In the female rat dosed at 10 mg/kg/day ICI 153110 a mild focal arteritis is characterized by a predominantly and diffusely adventitial infiltration of mixed cells and early formation of fibrous tissue. The two rats dosed at 250 mg/kg/day ICI 153110 die prematurely from intratracheal intubation of dosing solution. Arteries from two further animals (dosed at 5 and 250 mg/kg/day ICI 153110) show minimal focal arteritis with medial necrosis, and medial and adventitial inflammation[1]. MCE尚未独立确认这些方法的准确性。 仅供参考。

分子量：201.22

Formula：C11H11N3O

运输条件：美国大陆地区的室温；其他地区可能有所不同。

储存方式：请按照分析证书中推荐的条件储存产品。

Animal Administration [1]：Alderley Park APfSD rats are used in this study. In all, 150 male rats and 150 female rats are assigned to four groups (one control and three treatment) in the two separate studies; 30 per sex representing the main (regular) test groups and 15 per sex for investigating reversibility of effects following treatment at the highest dose employed (withdrawal studies). The dose levels are 5, 10, and 250 mg/kg/day of ICI 153110. All animals are dosed orally, by gavage, using a plastic syringe and a flexible catheter. Equal numbers of animals per sex in the four groups are necropsied necropsied at each of two time points; following at least 28 consecutive days dosing (1 month) and 182 consecutive days of dosing (6 months). All animals are observed at least twice daily for any abnormal signs, all of which are recorded. Body weights, food consumption, water consumption, clinical pathology, and pharmacokinetics are also measured[1]. MCE尚未独立确认这些方法的准确性。 仅供参考。

提供质量检测报告：Data Sheet、产品使用指南

产品活性：ICI 153110 是一种口服有效的磷酸二酯酶 (phosphodiesterase) 抑制剂，具有血管舒张和收缩力性质，可用于充血性心力衰竭的相关研究。

IC50 & Target：Phosphodiesterase[1]

相关产品：Cilostamide | Ro 20-1724 | MY-5445 | Roflumilast N-oxide | PDE1-IN-2 | PDE7-IN-3 | Cilostamide (Standard) | W⁻⁷ hydrochloride | Roflumilast N-oxide (Standard) | CI-1044 | Sp-cAMPS sodium salt | Ro 20-1724 (Standard)

热门产品线：抑制剂 | 稳定性同位素标记物 | 脂质 | 糖类

Trending products：Inhibitors | Isotope-Labeled Compounds | Lipids | Saccharides

参考文献：
[1]. Westwood FR, et al. Pathologic changes in blood vessels following administration of an inotropic vasodilator (ICI 153,110) to the rat. Fundam Appl Toxicol. 1990 May;14(4):797-809.