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talipexole dihydrochloride is a dopamine d2 receptor agonist, α2-adrenoceptor agonist, and 5-ht3 receptor antagonist in both rat cortical and intestinal membrane fractions with ki values of 0.35 μm and 0.22 μm, respectively. it displays antiparkinsonian a
更新时间:2025-07-07
balovaptan is a highly potent and selective brain-penetrant vasopressin 1a (hv1a) receptor antagonist, with kis of 1 and 39 nm for human (hv1a) and mouse (mv1a) receptors. it is used for the research of autism.
更新时间:2025-07-07
baloxavir is a first-in-class cap-dependent endonuclease inhibitor of the influenza virus polymerase pa subunit.
更新时间:2025-07-07
bamb-4 is a highly membrane-permeable inhibitor of inositol-1,4,5-trisphosphate-3-kinase a (itpka). it acts by suppressing the metastasis-promoting effect of itpka in lung tumor cells(with ic50 of 37 μm in adp-glo assay).
更新时间:2025-07-07
bay-2402234 is an inhibitor of dihydroorotate dehydrogenase (dhodh) for the treatment of myeloid malignancies.bay 2402234 is a selective low-nanomolar inhibitor of human dhodh enzymatic activity.
更新时间:2025-07-07
bay-524 is an inhibitor of bub1(ic50 = 450 nm.human bub1 in the presence of 2 mm atp).
更新时间:2025-07-07
levofloxacin is a broad-spectrum, third-generation fluoroquinolone antibiotic and optically active l-isomer of ofloxacin with antibacterial activity. levofloxacin diffuses through the bacterial cell wall and acts by inhibiting dna gyrase (bacterial topois
更新时间:2025-07-07
bay1082439 is highly effective in inhibiting pten-null prostate cancer growth[1][2] and it is an orally bioavailable, selective pi3kα/β/δ inhibitor. bay1082439 also inhibits mutated forms of pik3ca.
更新时间:2025-07-07
axitinib is an orally bioavailable tyrosine kinase inhibitor with ic50s of 0.1, 0.2, 0.1-0.3, 1.7, 1.6 nm for vegfr1, vegfr2, vegfr3, c-kit, and pdgfrβ, respectively.
更新时间:2025-07-07
beaucage reagent, which is found to be effective in causing dna cleavage.
更新时间:2025-07-07
phenformin is an agent belonging to the biguanide class of antidiabetics with antihyperglycemic activity.
更新时间:2025-07-07
nialamide is an mao inhibitor that is used as an antidepressive agent.
更新时间:2025-07-07
bi-1935 is an inhibitor of soluble epoxide hydrolase (seh). for diseases related to cardiovascular disease.
更新时间:2025-07-07
bi-3812 is an inhibitor of bcl6. which inhibiting the btb domain of bcl6 (ic50: 3 nm). bi-3812 also has antitumor activity.
更新时间:2025-07-07
bi-671800 is a highly specific and potent antagonist of chemoattractant receptor-homologous molecule on th2 cells (dp2/crth2). with ic50 values of 4.5 nm and 3.7 nm for pgd2 binding to crth2 in hcrth2 and mcrth2 transfected cells, respectively. bi-671800
更新时间:2025-07-07
deferasirox is an oral iron chelating agent used to treat chronic iron overload.
更新时间:2025-07-07
bifenazate is a positive allosteric modulator of gaba receptor. bifenazate is an acaricide that controls 100% of mites at a concentration of 25 ppm.
更新时间:2025-07-07
biotin-dadoo is a biotinylation reagent,which can be used to synthesize a biotin-estradiol conjugate (i.e., biotin-dadoo-estradiol) to develop a direct, broad range enzyme immunoassay to measure plasma estradiol concentrations.
更新时间:2025-07-07
biotin hydrazide is a carbonyl-reactive biotinylation reagent, which is a carbonyl probe. biotin hydrazide is a great choice for labeling mouse monoclonal antibodies, lectins, sugars, unpaired cytosine residues in nucleic acids, and glycoprotiens.
更新时间:2025-07-07
biotin nhs is an amino reactive biotin reagent used in the preparation of biotinylated surfaces or polypeptides.
更新时间:2025-07-07
epalrestat, an aldose reductase inhibitor, is well tolerated in long-term therapy. it can effectually ameliorate the associated symptoms of diabetic neuropathy and delay the progression of the disease, particularly in patients with limited microangiopathy
更新时间:2025-07-07
biotin-peg3-acid is a biotin-labeled, peg-based protac linker that can be used in the synthesis of protacs.biotin-peg3-acid is a heterobiofunctional biotin peg derivative containing a carboxylic acid group. the hydrophilic peg spacer arm imparts water sol
更新时间:2025-07-07
cisatracurium besylate is a nondepolarizing skeletal muscle relaxant for intravenous administration.
更新时间:2025-07-07
biotin-peg3-azide is a peg-based protac linker can be used in the synthesis of protacs.
更新时间:2025-07-07
biotin-peg4-alkyne is a biotin-labeled, peg-based protac linker that can be used in the synthesis of protacs.
更新时间:2025-07-07
dicyclomine hydrochloride is a muscarinic antagonist used as an antispasmodic and in urinary incontinence.
更新时间:2025-07-07
candesartan is an angiotensin ii receptor blocker used widely in the therapy of hypertension and heart failure.
更新时间:2025-07-07
captopril is a potent and specific inhibitor of peptidyl-dipeptidase a. it blocks the conversion of angiotensin i to angiotensin ii, a vasoconstrictor and important regulator of arterial blood pressure.
更新时间:2025-07-07
ramelteon is a melatonin receptor agonist. the mechanism of action of ramelteon is as a melatonin receptor agonist.
更新时间:2025-07-07
bis-peg3-nhs ester is a nonclaevable 3-unit peg linker for antibody-drug-conjugation (adc).
更新时间:2025-07-07
toremifene citrate is a selective estrogen receptor modulator (serm). it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on the mammary and uterine tissue.
更新时间:2025-07-07
mupirocin is a rna synthetase inhibitor antibacterial. it has shown excellent activity against gram-positive staphylococci and streptococci.
更新时间:2025-07-07
nadifloxacin has been used in trials studying the treatment of acne vulgaris.
更新时间:2025-07-07
motixafortide is an antagonist of cxcr4 with ic50 of ～1 nm. it induces the apoptosis of aml blasts by down-regulating erk, bcl-2, mcl-1 and cyclin-d1 via altered mir-15a/16-1 expression.
更新时间:2025-07-07
acemetacin is a carboxymethyl ester of indometacin. it is a potent non-steroidal anti-inflammatory drug, derived from the indol-3-acetic acid, whose activity is thought to be mainly through its active metabolite indomethacin. in clinical trials, acemetaci
更新时间:2025-07-07
lornoxicam (chlortenoxicam) is a new nonsteroidal anti-inflammatory drug (nsaid) of the oxicam class with analgesic, anti-inflammatory, and antipyretic properties. lornoxicam differs from other oxicam compounds in its potent inhibition of prostaglandin bi
更新时间:2025-07-07
bms-986158 is a potent bet inhibitor with ic50s of 6.6 and 5 nm in nci-h211 small cell lung cancer (sclc) cells and mda-mb231 triple negative breast cancer (tnbc) cells, respectively.
更新时间:2025-07-07
bms-986165 inhibits il-12/23 and type i ifn pathways[1][2]. bms-986165 is a highly selective, orally bioavailable allosteric tyk2 inhibitor for the treatment of autoimmune diseases. which selectively binds to tyk2 pseudokinase (jh2) domain (ic50=1.0 nm) a
更新时间:2025-07-07
levocetirizine is a histamine-1 receptor antagonist. the mechanism of action of levocetirizine is as a histamine h1 receptor antagonist.
更新时间:2025-07-07
bmx-in-1 is a selective inhibitor of bone marrow tyrosine kinase on chromosome x (bmx, ic50 = 8 nm) and the related bruton’s tyrosine kinase (btk, ic50 = 10.4 nm), but bmx-in-1 is more than 47-656 fold less potent against blk, jak3, egfr, itk, or tec acti
更新时间:2025-07-07
bnc105 is a tubulin polymerization inhibitor. it has potent antiproliferative and tumor vascular disrupting properties.
更新时间:2025-07-07
fexofenadine is a second generation antihistamine that is used for the treatment of allergic rhinitis, angioedema and chronic urticaria.
更新时间:2025-07-07
fexofenadine hydrochloride is a carboxylated metabolic derivative of terfenadine and long-lasting selective histamine h1 receptor antagonist, with antihistaminic activity.
更新时间:2025-07-07
duloxetine hydrochloride is a thiophene derivative and selective neurotransmitter uptake inhibitor for serotonin and noradrenaline (snri). it is an antidepressive agent and anxiolytic and is also used for the treatment of pain in patients with diabetes me
更新时间:2025-07-07
trospium is an antispasmodic and anticholinergic agent used to treat urinary incontinence and overactive bladder syndrome. trospium has not been implicated in causing liver enzyme elevations or clinically apparent acute liver injury.
更新时间:2025-07-07
trilostane is a synthetic derivative of androstane with adrenocortical suppressive properties. trilostane reversibly inhibits 3 beta-hydroxysteroid dehydrogenase delta 5-4 isomerase in the adrenal cortex.
更新时间:2025-07-07
otilonium bromide, an antimuscarinic, is utilized as a spasmolytic agent.
更新时间:2025-07-07
boc-nh-peg3-ch2cooh is a peg-based protac linker can be used in the synthesis of protac[1].
更新时间:2025-07-07
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