轴索过度生长抑制因子-A抗体

Cy5.5 Cy7 FITC Gold HRP PE PE-Cy3 PE-CY5 PE-CY5.5 PE-CY7 RBITC

英文名称 Anti-Nogo-A

中文名称 轴索过度生长抑制因子-A抗体

别 名 Nogo A; ASY; Foocen; Human NogoA; KIAA0886; My043 protein; Nbla00271; Nbla10545; Neurite growth inhibitor 220; Neurite Outgrowth Inhibitor; Neuroendocrine specific protein; Neuroendocrine specific protein C homolog; NI220/250; Nogo A; NOGO; Nogo protein; NogoA; NSP; NSP CL; Reticulon 4; Reticulon 5; Reticulon4; Reticulon5; RTN 4; RTN 4A; RTN X; RTN xL; RTN4 A; RTN4; RTN4 B1; RTN4 B2; RTN4 C; RTN4 protein; RTN4_HUMAN; Reticulon-4; Neuroendocrine-specific protein.

轴索过度生长抑制因子-A抗体浓 度 1mg/1ml

抗体来源 Rabbit

克隆类型 polyclonal

交叉反应 Human, Mouse, Rat,

产品类型 一抗

研究领域 细胞生物 神经生物学

蛋白分子量 predicted molecular weight: 131kDa

性 状 Lyophilized or Liquid

免 疫 原 KLH conjugated synthetic peptide derived from human RTN4 protein

亚 型 IgG

纯化方法 affinity purified by Protein A

储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA ａnd 0.1% Sodium azide

轴索过度生长抑制因子-A抗体产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500

（石蜡切片需做抗原修复）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

相关产品 免疫组化常用试剂 免疫印迹常用试剂 各种标记二抗

轴索过度生长抑制因子-A抗体产品介绍This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, ａnd are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. The product of this gene is a potent neurite outgrowth inhibitor which may also help block the regeneration of the central nervous system in higher vertebrates. Alternatively spliced transcript variants derived both from differential splicing ａnd differential promoter usage ａnd encoding different isoforms have been identified.

Function : Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion ａnd growth, ａnd as a facilitator of neurite branching. Regulates neurite fasciculation, branching ａnd extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring ａnd restriction of plasticity in the adult CNS. Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity). Isoform 2 reduces the anti-apoptotic activity of Bcl-xl ａnd Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding ａnd sequestration. Isoform 2 ａnd isoform 3 inhibit BACE1 activity ａnd amyloid precursor protein processing.

Subunit : Binds to RTN4R. Interacts with Bcl-xl ａnd Bcl-2. Isoform 2 binds to NGBR ａnd RTN3. Isoform 2 ａnd isoform 3 interact with BACE1 ａnd BACE2. Interacts with RTN4IP1. Interacts with ATL1.

Subcellular Location : Endoplasmic reticulum membrane. Anchored to the membrane of the endoplasmic reticulum through 2 putative transmembrane domains.

Tissue Specificity : Isoform 1 is specifically expressed in brain ａnd testis ａnd weakly in heart ａnd skeletal muscle. Isoform 2 is widely expressed except for the liver. Isoform 3 is expressed in brain, skeletal muscle ａnd adipocytes. Isoform 4 is testis-specific.

Similarity : Contains 1 reticulon domain.

Database links :

Entrez Gene: 57142 Human

Entrez Gene: 68585 Mouse

Entrez Gene: 83765 Rat

Omim: 604475 Human

SwissProt: Q9NQC3 Human

SwissProt: Q99P72 Mouse

SwissProt: Q9JK11 Rat

Unigene: 704007 Human

神经生物学相关蛋白（Neurobiology）

Nogo-A轴索生长抑制因子在中枢神经的髓鞘上表达并在抑制损伤轴索修复中起着关键作用，从而有限制神经功能恢复的现象。主要定位细胞核。