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ATRN吸引素抗体
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价格：￥电议
更新日期：2026/9/8 4:13:06
生 产 地：其它
产品型号：BY-1528R
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相关标签：ATRN,吸引素抗体,ATRN吸引素抗体
详细内容
本公司经销ATRN，吸引素抗体，克隆类型为polyclonal，宿主来源是Rabbit，ATRN吸引素抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！
货号：BY-1528R
英文名称：Anti-ATRN
中文名称：吸引素抗体
其他名称：ATRN; attractin-2; DPPT-L; KIAA0548; Mahogany homolog; mahogany protein; MGCA.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 133kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, dog, pig, Rb
产品介绍：Attractin is a serum glycoprotein of 175 kDaand found in both membrane-bound ａnd secreted forms as a result of alternative splicing. Both the secreted ａnd membrane-bound forms of attractin may be involved in the development ａnd maintenance of the central nervous system. Membrane-bound attractin is a co-receptor for Agouti, antagonist of melanocortin-1 receptor. Secreted attractin, expressed by activated T lymphocytes ａnd modulates interactions between T cells ａnd monocytes/macrophages, was examined as a potential marker of immune activity. Attractinmay be a component of a pathway for regulated protein turnover that also involves mahogunin, a wide-expressed E3 ubiquitinligase found at particularly high levels in the brain. Attractinwas considered as an extracellular target amenable for the development of obesity-regulating drugs, also.Function : Involved in the initial immune cell clustering during inflammatory response ａnd may regulate chemotactic activity of chemokines. May play a role in melanocortin signaling pathways that regulate energy homeostasis ａnd hair color. Low-affinity receptor for agouti （By similarity）. Has a critical role in normal myelination in the central nervous system （By similarity）.Subunit : Monomer ａnd homotrimer.Subcellular Location : Isoform 1: Cell membrane; Single-pass type I membrane protein.Isoform 2: Secreted.Isoform 3: Secreted.Tissue Specificity : Isoform 2 is detected in plasma （at protein level）. Expressed ａnd secreted by activated T-lymphocytes. Expressed at low to moderate levels in peripheral blood leukocytes, spleen, lymph node, tonsil, bone marrow ａnd fetal liver. At very low levels found in thymus. Isoform 2 is the major isoform in peripheral blood leukocytes.Post-translational modifications : Heavily glycosylated.Similarity : Contains 1 C-type lectin domain.Contains 1 CUB domain.Contains 1 EGF-like domain. Contains 6 Kelch repeats.Contains 2 laminin EGF-like domains.Contains 4 PSI domains.ATRN主要是参与肥胖基因的调节，在大脑中的表达水平与抑制肥胖症成正相关，并在协调T细胞与巨噬细胞之间的反应等方面起着十分重要的作用。
货号：BY-1528R
英文名称：Anti-ATRN
中文名称：吸引素抗体
其他名称：ATRN; attractin-2; DPPT-L; KIAA0548; Mahogany homolog; mahogany protein; MGCA.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 133kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, dog, pig, Rb
产品介绍：Attractin is a serum glycoprotein of 175 kDaand found in both membrane-bound ａnd secreted forms as a result of alternative splicing. Both the secreted ａnd membrane-bound forms of attractin may be involved in the development ａnd maintenance of the central nervous system. Membrane-bound attractin is a co-receptor for Agouti, antagonist of melanocortin-1 receptor. Secreted attractin, expressed by activated T lymphocytes ａnd modulates interactions between T cells ａnd monocytes/macrophages, was examined as a potential marker of immune activity. Attractinmay be a component of a pathway for regulated protein turnover that also involves mahogunin, a wide-expressed E3 ubiquitinligase found at particularly high levels in the brain. Attractinwas considered as an extracellular target amenable for the development of obesity-regulating drugs, also.Function : Involved in the initial immune cell clustering during inflammatory response ａnd may regulate chemotactic activity of chemokines. May play a role in melanocortin signaling pathways that regulate energy homeostasis ａnd hair color. Low-affinity receptor for agouti （By similarity）. Has a critical role in normal myelination in the central nervous system （By similarity）.Subunit : Monomer ａnd homotrimer.Subcellular Location : Isoform 1: Cell membrane; Single-pass type I membrane protein.Isoform 2: Secreted.Isoform 3: Secreted.Tissue Specificity : Isoform 2 is detected in plasma （at protein level）. Expressed ａnd secreted by activated T-lymphocytes. Expressed at low to moderate levels in peripheral blood leukocytes, spleen, lymph node, tonsil, bone marrow ａnd fetal liver. At very low levels found in thymus. Isoform 2 is the major isoform in peripheral blood leukocytes.Post-translational modifications : Heavily glycosylated.Similarity : Contains 1 C-type lectin domain.Contains 1 CUB domain.Contains 1 EGF-like domain. Contains 6 Kelch repeats.Contains 2 laminin EGF-like domains.Contains 4 PSI domains.ATRN主要是参与肥胖基因的调节，在大脑中的表达水平与抑制肥胖症成正相关，并在协调T细胞与巨噬细胞之间的反应等方面起着十分重要的作用。
ATRN,吸引素抗体,ATRN吸引素抗体
