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Estrogen receptors (ER)抗体
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上传时间：2012/10/23 13:46:41
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上 传 者：上海博耀生物科技有限公司
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Estrogen receptors （ER） are members of the steroid/thyroid hormone receptor
superfamily of ligand-activated transcription factors. Estrogen receptors, including
ERα ａnd ERβ, contain DNA binding ａnd ligand binding domains and
are critically involved in regulating the normal function of reproductive tissues.
They are located in the nucleus, though some estrogen receptors associate
with the cell surface membrane ａnd can be rapidly activated by exposure of
cells to estrogen. ERα ａnd ERβ have been shown to be differentially activated
by various ligands. Receptor-ligand interactions trigger a cascade of events,
including dissociation from heat shock proteins, receptor dimerization, phosphorylation
and the association of the hormone activated receptor with specific
regulatory elements in target genes. Evidence suggests that ERα and
ERβ may be regulated by distinct mechanisms even though they share many
functional characteristics.
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