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Anti-BMP15 antibody [EPR5137]

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文件大小：3kb

上传时间：2012/10/22 8:33:18

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上传者：上海博耀生物科技有限公司

查看次数：227次

下载次数：51次

Product overview
Description Rabbit monoclonal [EPR5137] to BMP15
Host species Rabbit
Tested applications WB, Flow Cyt
Cross reactivity Reacts with
Mouse, Rat, Human
Immunogen Synthetic peptide corresponding to residues near the C terminus of Human BMP15.
Positive control Ovary cancer, uterus, HL-60, NIH:OVCAR-3, Human testis, ａnd HeLa cell lysates; Hela cells
General notes Produced under U.S. Patent No. 5,675,063.
Target
Function May be involved in follicular development. Oocyte-specific growth/differentiation factor that stimulates folliculogenesis ａnd granulosa cell
（GC） growth.
Involvement in disease Defects in BMP15 are the cause of ovarian dysgenesis type 2 （ODG2） [MIM:300510]; also known as X-linked hypergonadotropic
ovarian dysgenesis or hypergonadotropic ovarian failure due to ovarian dysgenesis. Ovarian dysgenesis leads to ovarian failure and
accounts for about half of the cases of primary amenorrhea.
Defects in BMP15 are the cause of premature ovarian failure type 4 （POF4） [MIM:300510]. An ovarian disorder defined as the
cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of
elevated levels of serum gonadotropins ａnd low estradiol.
Sequence similarities Belongs to the TGF-beta family.
Cellular localization Secreted.