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4-Bromo-6-fluoroquinoline (CAS number 661463-17-8) is a dihalogenated quinoline, a benzene-fused pyridine bicyclic heterocycle. Quinoline derivatives are widely used as active pharmaceutical ingredients (APIs). 4-Bromo-6-fluoroquinoline is applied in the synthesis of linrodostat, an inhibitor of amine 2,3-dioxygenase for anti-cancer treatments. The reactivity of 4-bromo-6-fluoroquinoline includes Pd-catalyzed coupling reactions on the bromide group and nucleophilic aromatic substitution on the fluoride group.
As an aromatic bicyclic compound, 4-bromo-6-fluoroquinoline can also be used in the preparation of dyes for the applications of OLEDs and solar cells.
| CAS Number | 661463-17-8 |
| Chemical Formula | C9H5BrFN |
| Full Name | 4-Bromo-6-fluoroquinoline |
| Molecular Weight | 226.05 g/mol |
| Synonyms | N/A |
| Classification / Family | Fluorinated building blocks, Heterocyclic building blocks, Quinoline building blocks, APIs, Dyes |
| Purity | 98% |
| Melting Point | Tm= 77 °C – 78 °C |
| Appearance | Off-white powder |
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