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更新时间：2026/10/14 9:05:15关注度：65
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4-Amino-2-(trifluoromethyl)pyridine (CAS number 147149-98-2) has an amine and a trifluoromethyl group substituted on its pyridine core. 4-Amino-2-(trifluoromethyl)pyridine are involved in many syntheses of active pharmaceutical ingredients (APIs), such as naporafenib, a RAF inhibitor used in the treatment of RAF-driven cancers. 4-Amino-2-(trifluoromethyl)pyridine can also be used for synthesizing pyridine-based ligands to stabilize hypervalent iodine which is applied in a wide range of synthetic transｆormations.
4-Amino-2-(trifluoromethyl)pyridine can undergo a Chichibabin reaction to introduce an additional amine group in the para-position. The resulting product is employed in the synthesis of oral checkpoint kinase inhibitor for immunotherapy.
| CAS Number | 147149-98-2 |
| Chemical Formula | C6H5F3N2 |
| Full Name | 2-(Trifluoromethyl)-4-pyridinamine |
| Molecular Weight | 162.11 g/mol |
| Synonyms | 2-(Trifluoromethyl)pyridin-4-amine, 2-Trifluoromethyl-4-amino-pyridine |
| Classification / Family | Fluorinated building blocks, Heterocyclic building blocks, Pyridine building blocks, APIs, Ligands |
| Purity | 98% |
| Melting Point | Tm= 58 °C – 62 °C |
| Appearance | White crystals |
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