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更新时间：2026/10/14 9:23:11关注度：44
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2-Fluoropyridine-3-carbonitrile (CAS number 3939-13⁻⁷), also named as 2-fluoronicotinonitrile, is a nicotinonitrile building block featuring a fluoride substituent at 2-position. 2-Fluoropyridine-3-carbonitrile commonly serves as a synthesis precursor for active pharmaceutical ingredients (APIs), such as niflumic acid that is used for joint and muscular pain relief. Pyrazopyridine, a bicyclic heterocycle can be synthesized from 2-fluoropyridine-3-carbonitrile. The reaction begins with a nucleophilic aromatic substitution of hydrazine, followed by a pyrazole cyclization reaction.
Additionally, 2-fluoropyridine-3-carbonitrile can be modified through Minisci reaction for ｍmbed- and para-alkylation.
| CAS Number | 3939-13⁻⁷ |
| Chemical Formula | C6H3FN2 |
| Full Name | 2-Fluoronicotinonitrile |
| Molecular Weight | 122.10 g/mol |
| Synonyms | 3-Cyano-2-fluoropyridine |
| Classification / Family | Fluorinated building blocks, Heterocyclic building blocks, Nicotinonitrile building blocks, APIs |
| Purity | 98% |
| Melting Point | Tm= 28 °C – 33 °C |
| Appearance | White crystals |
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