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更新时间：2026/10/14 9:23:11关注度：95
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tetrahydroquinoline-based glucocorticoid receptor agonist commences with 3-chloro-5-fluoroaniline reacting with acetone and iodine under Skraup reaction.
The presence of chlorine and fluorine substituents in 3-chloro-5-fluoroaniline enables further functionalization, such as palladium-catalyzed carbon-carbon coupling and nucleophilic aromatic substitution.
| CAS Number | 4863-91-6 |
| Chemical Formula | C6H5ClFN |
| Full Name | 3-Chloro-5-fluoroaniline |
| Molecular Weight | 145.56 g/mol |
| Synonyms | 3-Chloro-5-fluorobenzenamine |
| Classification / Family | Fluorinated building blocks, Aniline building blocks, APIs |
| Purity | 97% |
| Boiling Point | Tb= 226 °C at 760 mmHg |
| Relative Density | 1.45 g/mL |
| Appearance | Clear liquid |
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