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更新时间：2026/10/14 9:23:11关注度：76
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3-Fluoro-4-methoxybenzoic acid (CAS number 403-20-3) is a fluorinated para-anisic acid derivative. The fluoride substituent enables nucleophilic aromatic substitution, while most of the reactivity centered on the carboxylic group. 3-Fluoro-4-methoxybenzoic acid can undergo various reactions, including Fischer esterification affording esters with ligustrazine moiety for the treatment of Alzheimer's disease.
Furthermore, 3-Fluoro-4-methoxybenzoic acid can be transｆormed into benzoyl chloride using thionyl chloride to enhance its reactivity, thereby providing a platｆorm for Friedel-Craft acylation reaction. Additionally, 3-Fluoro-4-methoxybenzoic acid can be modified into hydrazide which is used in the synthesis of oxadiazoles for antimicrobial applications.
| CAS Number | 403-20-3 |
| Chemical Formula | C8H7FO3 |
| Full Name | 3-Fluoro-4-methoxybenzoic acid |
| Molecular Weight | 170.14 g/mol |
| Synonyms | 3-Fluoro-p-anisic Acid |
| Classification / Family | Fluorinated building blocks, Benzoic acid building blocks, Anisic acid building blocks, APIs |
| Purity | 98% |
| Melting Point | Tm= 211 °C – 213 °C |
| Appearance | White powder |
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