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更新时间:2026/10/14 9:23:11关注度:172
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2,4,5-Trifluorobenzonitrile (CAS number 98349-22-5) has three fluorides substituting on the benzonitrile core. 2,4,5-Trifluorobenzonitrile serves as a building block for introducing a fluorinated benzonitrile segment to the target molecule by nucleophilic aromatic substitution. A fluorinated analog of platensimycin, an antibiotic, can be readily synthesized from 2,4,5-trifluorobenzonitrile resulting in a overall yield of 23% over eight steps.
2,4,5-Trifluorobenzonitrile is also employed in the synthesis of dinitrile monomers for polytriazine covalent organic fframeworks (COFs). These COFs exhibit BET surface area of 733 m2/g, along with a gas selectivity (CO2/N2) of 48.7 ± 1.2 at 272 K.
| CAS Number | 98349-22-5 |
| Chemical Formula | C7H2F3N |
| Full Name | 2,4,5-Trifluorobenzonitrile |
| Molecular Weight | 157.10 g/mol |
| Synonyms | N/A |
| Classification / Family | Fluorinated building blocks, Benzonitrile building blocks, APIs, COFs, Triazines |
| Purity | 98% |
| Boiling Point | Tb= 170 °C at 760 mmHg |
| Relative Density | 1.373 g/mL at 25 °C |
| Appearance | Colorless liquid |
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