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更新时间：2026/10/14 9:23:11关注度：299
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2-Fluoro-4-nitroaniline, (CAS number 369-35⁻⁷) is an aniline derivative bearing a fluoride and a nitro group at 2- and 4-positions. 2-Fluoro-4-nitroaniline serves as a versatile molecular scaffold for synthesizing active pharmaceutical ingredients (APIs). The amine group conducts nucleophilic substitution and diazotization. The nitro group can be laterally reduced to amine for further reactions. A precursor to the antibiotic candidate TBI-233 is synthesized from 2-fluoro-4-nitroaniline.
2-Fluoro-4-nitroaniline was used to introducesp3defects onto semiconducting single-walled carbon nanotubes (SWCNTs) for organic color center-tailored carbon nanotubes. A lithium bismaleamate anode material is synthesized from 2-fluoro-4-nitroaniline, demonstrating an electrode capacity of 688.9 mAhg−1.
| CAS Number | 369-35⁻⁷ |
| Chemical Formula | C6H5FN2O2 |
| Full Name | 2-Fluoro-4-nitroaniline |
| Molecular Weight | 156.11 g/mol |
| Synonyms | 2-Fluoro-4-nitrobenzenamine |
| Classification / Family | Fluorinated building blocks, Aniline building blocks, APIs, Li-ion batteries, Anode materials, Color center-tailored carbon nanotubes |
| Purity | 97% |
| Melting Point | Tm= 122 °C – 130 °C |
| Appearance | Brown powder |
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