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更新时间:2026/10/14 9:23:11关注度:293
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3-Fluoro-2-methylbenzoic acid (CAS number 699-90-1) is derived from methylbenzoic acid, also known as ortho-toluic acid. Acetoxy-methylbenzoic anhydride is synthesized from 3-fluoro-2-methylbenzoic acid, demonstrating antibiotic activity with minimum inhibitory concentration (MIC) of 500–1000 µg/mL. Diarylmethanes, which are novel building blocks for sodium-glucose transporter 2 (SGLT2) inhibitors can be obtained from 3-fluoro-2-methylbenzoic acid through Friedel-Crafts acylation, followed by a reduction reaction.
The positioning of the carboxylic acid and fluoride at the mmbed-position renders 3-fluoro-2-methylbenzoic acid a structural scaffold for bent-core liquid crystals.
| CAS Number | 699-90-1 |
| Chemical Formula | C8H7FO2 |
| Full Name | 3-Fluoro-2-methylbenzoic acid |
| Molecular Weight | 154.14 g/mol |
| Synonyms | 3-Fluoro-o-toluic acid |
| Classification / Family | Fluorinated building blocks, Benzoic acid derivatives, APIs, Liquid crystals |
| Purity | 98% |
| Melting Point | Tm = 158 °C – 160 °C |
| Appearance | White powder |
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