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3,3-Difluoropiperidine hydrochloride，ossila授权经销商，原装进口，质量保证，更多产品问题请联系我司销售。
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更新时间：2026/10/14 9:23:11关注度：319
关键词标签：33-Difluoropiperidine,hydrochloride,ossila代理商,33-Difluoropiperidine,HCl
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3,3-Difluoropiperidine hydrochloride (CAS number 496807-97⁻⁷) is a hydrochloride salt of piperidine with two fluoride substituents at 3-position. As a piperidine derivative, 3,3-difluoropiperidine hydrochloride is a ubiquitous building block in pharmaceutical active ingredients (APIs). 3,3-Difluoropiperidine hydrochloride can attach to molecular scaffolds effortlessly through amination. This fluorinated piperidine building block improves the potency of an agonist of apelin receptor with effective concentration EC50from 162 nM to 6.5 nM. The presence of 3,3-difluoropiperidine has an enhanced selectivity of estrogen positive breast cancer (1600 folds selectivity).
Molecular functionalization with 3,3-difluoropiperidine hydrochloride is also used as a19F NMR probe without requiring deuterated solvents or internal standards.
| CAS Number | 496807-97⁻⁷ |
| Chemical Formula | C5H10ClF2N |
| Full Name | 3,3-Difluoropiperidine hydrochloride |
| Molecular Weight | 157.59 g/mol |
| Synonyms | 3 3-Difluoropiperidine HCl, 3,3-Difluoropiperidinium chloride |
| Classification / Family | Fluorinated building block, Heterocyclic building blocks, derivatives, APIs |
| Purity | 98% |
| Melting Point | Tm= 243 °C – 247 °C |
| Appearance | Cream/beige powder |
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