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更新时间：2026/10/14 9:23:11关注度：309
关键词标签：3,-,氟对甲氧基苯胺,3-氟-4-甲氧基苯胺,氟代对甲氧基苯胺
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3-Fluoro-p-anisidine (CAS number 366-99-4), also referred to as 3-fluoro-4-methoxyaniline, is an aniline with a fluoride and a methoxy substituted at 3- and 4-positions. 3-Fluoro-p-anisidine is commonly used as a precursor for synthesizing quinoline derivatives through Combes quinoline synthesis with 1,3-diketones. The as synthesized quinoline derivatives are employed as active pharmaceutical ingredients and dyes. 3-Fluoro-p-anisidine is readily attached to molecular scaffolds through nucleophilic substitution.
The primary amine in 3-fluoro-p-anisidine can be used to prepare azides for copper-catalyzed azide-alkyne cycloaddition (click reaction).
| CAS Number | 366-99-4 |
| Chemical Formula | C7H8FNO |
| Full Name | 3-Fluoro-4-methoxyaniline |
| Molecular Weight | 141.15 g/mol |
| Synonyms | 4-Amino-2-fluoroanisole, 3-Fluoro-4-methoxyaniline, 4-Amino-2-fluoro-1-methoxybenzene |
| Classification / Family | Fluorinated building blocks, Aniline building blocks, APIs, Heterocycles |
| Purity | 97% |
| Melting Point | Tm= 81 °C – 83 °C |
| Appearance | Brown powder |
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