3′-Fluoro-4′-methoxyacetophenone (CAS number 455-91-4) is an acetophenone derivative with a fluorine and a methoxy substituents. 3′-Fluoro-4′-methoxyacetophenone is used to prepare chalcone derivatives with benzaldehydes by aldol condensation. Chalcones are α,β-unsaturated ketones employed as active pharmaceutical ingredients (APIs) and fluorescent dyes. Pyrazole derivatives such as celecoxib, an anti-inflammatory drug, are obtained from chalcones reacting with hydrazine derivatives. Chalcone derivatives can be further functionalized to produce epoxides via Juliá–Colonna epoxidation.

3′-Fluoro-4′-methoxyacetophenone is also a key component in Mannich reaction along with ｆormaldehyde and secondary amines, for β-amino-carbonyl compounds, also known as Mannich bases.

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