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更新时间：2026/10/14 9:23:11关注度：126
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3-Fluoro-2-pyridinecarbonitrile (CAS number 97509⁻⁷5-6) is a pyridine derivative having a fluorine and a nitrile group at 3- and 2-positions. 3-Fluoro-2-pyridinecarbonitrile can undergo different reactions, such as nucleophilic aromatic substitutions on the fluorine substituted carbon. It allows 3-fluoro-2-pyridinecarbonitrile to attach to chromophores like carbazoles, for synthesizing aggregation-induced emission molecules. Such method is also applied to pharmaceutical compounds, by attaching 3-fluoro-2-pyridinecarbonitrile to negative allosteric modulator small molecules leading to an improved binding affinity to glutamate receptors for the treatment of central nervous system diseases.
3-Fluoro-2-pyridinecarbonitrile is also used to prepare tetrazine through bioorthogonal chemistry with hydrazine. The as-synthesized tetrazines facilitate additional reactions, including tetrazine ligation and [4+1] cycloaddition.
| CAS Number | 97509⁻⁷5-6 |
| Chemical Formula | C6H3FN2 |
| Full Name | 3-Fluoro-2-pyridinecarbonitrile |
| Molecular Weight | 122.10 g/mol |
| Synonyms | 2-Cyano-3-fluoropyridine, 3-fluoropicolinonitrile, 3-Fluoro-pyridine-2-carbonitrile |
| Classification / Family | Fluorinated building blocks, Heterocyclic building blocks, APIs, Aggregation-induced emission materials, Phosphorescence |
| Purity | 97% |
| Melting Point | Tm= 27 °C – 32 °C |
| Appearance | White crystals |
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