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N - 叔丁氧羰基 - 4,4 - 二氟 - L - 脯氨酸，ossila授权经销商，原装进口，质量保证，更多产品问题请联系我司销售。
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更新时间：2026/10/14 9:23:11关注度：134
关键词标签：N,-,叔丁氧羰基,-,44,-,二氟,-,L,-,脯氨酸,Boc-44-二氟-L-脯氨酸,44-二氟-L-脯氨酸Boc
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N-Boc-4,4-difluoro-l-proline (CAS number 203866-15-3) is a tert-butoxycarbonyl (Boc) protectedl-proline with two fluorine substituents at 4-position. N-Boc-4,4-difluoro-l-proline is an S-enantiomer, making it an excellent additive/catalyst in asymmetric reactions. In protein/peptide chemistry, N-Boc-4,4-difluoro-l-proline is introduced for conｆormational control favoring 78% cis-conｆormers. The conｆormation selectivity is also expressed in the19F NMR spectrum which is a powerful tool to study the isomerization of peptides and proteins.
N-Boc-4,4-difluoro-l-proline is also applied as a molecular scaffold for synthesizing fibroblast activation protein, a trans-membrane serine protease.
| CAS Number | 203866-15-3 |
| Chemical Formula | C10H15F2NO4 |
| Full Name | (S)-1-(tert-Butoxycarbonyl)-4,4-difluoro-2-pyrrolidinecarboxylic acid |
| Molecular Weight | 251.23 g/mol |
| Synonyms | N-(tert-Butoxycarbonyl)-4,4-difluoro-l-proline |
| Classification / Family | Fluorinated building blocks, Heterocyclic building blocks, Proteins, Peptides, Asymmetric synthesis, Chiral molecules |
| Purity | 97% |
| Melting Point | Tm= 120 °C – 140 °C |
| Optical Rotation | −44.19 ° (c = 1, methanol) |
| Appearance | Off-white powder |
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