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更新时间：2026/10/14 9:23:11关注度：127
关键词标签：3,-,氟,-,4,-,羟基苯甲醛,氟代羟基苯甲醛,3-氟-4-羟基苯甲醛应用
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3-Fluoro-4-hydroxybenzaldehyde (CAS number 405-05-0) is a fluorinated benzaldehyde bearing a fluorine and a hydroxy at 3- and 4-positions. 3-Fluoro-4-hydroxybenzaldehyde is used to synthesize analogs of curcuminoid with ketones through aldol condensation. The as synthesized curcuminoid derivatives show half maximal inhibitory concentration of 0.75 µM against human ovarian cancer cell line A2780. Hydrazone derivatives can be obtained from 3-fluoro-4-hydroxybenzaldehyde with a phenylhydrazine derivatives via aldehyde-amine condensation, showing potent inhibitory of macrophage migration in anti-inflammatory activity.
3-Fluoro-4-hydroxybenzaldehyde is also exploited to synthesize caffeic acid phenylethyl amide derivatives through Wittig reaction for cytoprotective activity against peroxides.
| CAS Number | 405-05-0 |
| Chemical Formula | C7H5FO2 |
| Full Name | 3-Fluoro-4-hydroxybenzaldehyde |
| Molecular Weight | 140.11 g/mol |
| Synonyms | 2-Fluoro-4-ｆormylphenol |
| Classification / Family | Fluorinated building blocks, building blocks, APIs |
| Purity | 97% |
| Melting Point | Tm= 121 °C – 124 °C |
| Appearance | Beige powder |
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