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3-Fluoro-4-morpholinoaniline (CAS number 93246-53-8) has a fluorinated aniline linked to a morpholine, a heterocycle featuring both amine and ether groups. By having the accessible primary amine, 3-fluoro-4-morpholinoaniline reacts with aldehyde to ｆorm Schiff bases. The Schiff base shows a better biofilm inhibition with IC50(half maximal inhibitory concentration) of 12.97 µM, compared with linezolid (IC50of 15.93 µM). 3-Fluoro-4-morpholinoaniline can also be modified for sulfonamide and carbamate derivatives that exhibit antimicrobial activity (minimum inhibitory concentration of 6.25-25.0 µg/mL).
4-Morpholinoaniline decorated phenylenediamine carbon nanodots show an improved photoluminescence quantum yield from 28.3% to 41.8%. The fluorinated 4-morpholinoaniline (3-fluoro-4-morpholinoaniline) can be applied to tune the emission wavelength of the carbon nanodots.
| CAS Number | 93246-53-8 |
| Chemical Formula | C10H13FN2O |
| Full Name | 3-Fluoro-4-morpholinoaniline |
| Molecular Weight | 196.22 g/mol |
| Synonyms | 4-(2-Fluoro-4-aminophenyl)morpholine, 3-Fluoro-4-morpholin-4-yl-phenylamine, 3-Fluoro-4-(4-morpholinyl)-benzenamine |
| Classification / Family | Fluorinated building block, Heterocyclic building block, Schiff base, Carbon nanodots, APIs, OLEDs, Antimicrobials |
| Purity | >98% |
| Melting Point | Tm= 121 °C – 123 °C |
| Appearance | Off-white to pale beige powder |
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