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更新时间：2026/10/14 9:23:11关注度：449
关键词标签：,6-Fluoro-2-carboxylic,acid,6,-,氟吲哚,-,2,-,羧酸,ossila材料
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6-Fluoro-2-carboxylic acid (CAS number 3093-97-8) is a fluorinated derivative, having a fluorine at 6-position and a carboxylic acid at 2-position. The secondary amine and carboxylic acid in 6-Fluoro-2-carboxylic acid ｆorm an α-amino acid moiety. This allows 6-fluoro-2-carboxylic acid to have a zwitterionic ｆorm where the proton of the carboxylic acid is transferred to the amine. In fluorescence spectra, the neutral ｆorm and zwitterionic ｆorm of 6-fluoro-2-carboxylic acid have different emission band at 332 and 370 nm respectively, ｆorming a broad fluorescence emission peak.
The carboxylic acid group in 6-fluoro-2-carboxylic acid can bind to copper(II), yielding a binuclear complex. The complex shows anti-cancer activity towards breast cancer cell lines (MDA-MB-231 and MCF⁻⁷) with percentage of inhibition of 90% at 20 µM concentration.
6-Fluoro-2-carboxylic acid can be used to synthesize tris, via a palladium catalyzed decarboxylative reaction. Tris are used as semiconductors in OFETs with field effect mobility of 0.03 cm2V-1S-1, as well as hole transport ｌayers in solar cells.
| CAS Number | 3093-97-8 |
| Chemical Formula | C9H6FNO2 |
| Full Name | 6-Fluoro-1H--2-carboxylic acid |
| Molecular Weight | 179.15 g/mol |
| Synonyms | N/A |
| Classification / Family | Fluorinated building block, Heterocyclic building block, APIs, OFETs, Solar cells, Semiconductors |
| Purity | 97% |
| Melting Point | Tm= 244 °C – 250 °C |
| Appearance | White to off-white powder |
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