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技术文章
文献引用产品：正常人皮肤黑色素细胞PIG1
点击次数：71 发布时间：2026/10/9 8:53:13
文章标题：Epigenetic downregulation of MAPKAPK2 exacerbates oxidative stress－induced damage in vitiligo melanocyte cell line model
作者列表：Yishan Wang, Xiaoyong Zheng
影响因子：3
期刊：Frontiers in Medicine
发表时间：2026－4－20
DOI:10.3389/fmed.2026.1698091
文献主题：Abstract
Background ｏbjective
Vitiligo is an acquired depigmentation disorder caused by melanocyte dysfunction or loss. Oxidative stress is widely considered a key driver to its pathogenesis. Mitogen－activated protein kinase－activated protein kinase 2 (MAPKAPK2) is implicated in oxidative stress responses, although its role in vitiligo remains uncertain. This study intended to investigate whether epigenetic downregulation of MAPKAPK2 aggravates oxidative stress－induced damage in vitiligo melanocytes.
Methods
Human melanocyte lines (PIG1 PIG3V) were used to model normal vitiligo conditions. The effects of oxidative stress, DNA demethylation (5－aza－DC), MAPKAPK2 overexpression were assessed using qRT－PCR, Western blot, ELISA, comet assay, TUNEL, CCK－8. Pharmacological inhibition of MK2 was employed to evaluate the functional requirement of MAPKAPK2 kinase activity, key antioxidant pathways, including Nrf2 signaling, were investigated.
原创作者：上海雅吉生物科技有限公司
