企业档案
会员类型：标准版
已获得阿仪网信誉 等级评定
(0 -40)基础信誉积累，可浏览访问
(41-90)良好信誉积累，可接洽商谈
(91+ )优质信誉积累，可持续信赖
阿仪网标准版会员：8年
工商认证 【已认证】
最后认证时间：无需年检
注册号：**** 【已认证】
法人代表：谭春** 【已认证】
参观次数：2676310
技术文章
文献引用产品|TCAM-2人睾丸精原瘤细胞
点击次数：812 发布时间：2026/4/21 15:44:55
文章标题：Inflammation-induced LncRNA SNHG1 orchestrates spermatogonium development in non-obstructive azoospermia via IL-17 A signaling pathway
作者列表：Yongtong Zhu, Maocai Li, Xiaomin Zhan, Li Liu, Cairong Chen, Yao Zhou, Pei He, Rui Hua
期刊：CELLULAR AND MOLECULAR LIFE SCIENCES
发表时间：2026-1-6
影响因子：6.2
DOI:10.1007/s00018-025-06055-3
主要研究成果：Abstract
Non-obstructive azoospermia (NOA) is a critical subtype of male infertility associated with inflammation. However, the molecular mechanisms underlying this phenomenon remain poorly understood. This study investigated the role of the inflammation-activated long non-coding RNA SNHG1 in NOA pathogenesis. Using lipopolysaccharide (LPS)-induced orchitis mouse models and spermatogonium cell lines (GC-1 spg and TCAM-2), we observed that both SNHG1 and the tranｓcription factor SP1 were significantly upregulated, correlating with spermatogonium proliferation and loss of stemness. Mechanistically, SP1 directly binds to and tranｓcriptionally activates the SNHG1 promoter, whereas SNHG1 knockdown rescued LPS-induced spermatogonium dysfunction without affecting SP1 expression. RNA-seq revealed that SNHG1 overexpression activated the IL-17 A signaling pathway. Notably, IL-17 A receptor blockade (Brodalumab) reversed the SNHG1-mediated proliferation arrest and stemness. Our findings demonstrated that the SP1-SNHG1-IL-17 A axis drives inflammatory spermatogenic failure, suggesting IL-17 A inhibition as a potential therapeutic direction.
原创作者：上海雅吉生物科技有限公司
