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磷酸化干扰素调节因子7抗体3196
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品牌名称：$brandModel.Title型号：3196 原产地：中国大陆 更新时间：2026/10/21 9:04:14
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详细内容
中文名称磷酸化干扰素调节因子7抗体
别 名Interferon regulatory factor 7; Interferon regulatory factor 7H; IRF 7; IRF 7A; IRF 7H; IRF7A; IRF7; IRF7H.
产品类型 磷酸化抗体
研究领域 肿瘤 信号转导 细胞凋亡 转录调节因子
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, (predicted: Pig, Cow, Horse, )
产品应用 WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:100-500 Flow-Cyt=1ug/test （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 54kDa
细胞定位 细胞核 细胞浆
性 状 Liquid
浓 度 1mg/ml
免 疫 原 KLH conjugated synthesised phosphopeptide derived from human IRF7 around the phosphorylation site of Ser471/472:GV(p-S)(p-S)LD
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed PubMed
产品介绍 IRF7 encodes interferon regulatory factor 7, a member of the interferon regulatory tranｓcription factor (IRF) family. IRF7 has been shown to play a role in the tranｓcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. Inducible expression of IRF7 is largely restricted to lymphoid tissue. Multiple IRF7 tranｓcript variants have been identified, although the functional consequences of these have not yet been established. [provided by RefSeq, Jul 2008]
Function:
Tranｓcriptional activator. Binds to the interferon-stimulated response element (ISRE) in IFN promoters and in the Q promoter (Qp) of EBV nuclear antigen 1 (EBNA1). Functions as a molecular switch for antiviral activity. Activated by phosphorylation in response to infection. Activation leads to nuclear retention, DNA binding, and derepression of transactivation ability.
Subunit:
Homodimer.
Subcellular Location:
Nucleus. Cytoplasm. The phosphorylated and active ｆorm accumulates selectively in the nucleus.
Tissue Specificity:
Expressed predominantly in spleen, thymus and peripheral blood leukocytes.
Post-translational modifications:
In response to a viral infection, phosphorylated on the C-terminal serine cluster. Phosphorylation, and subsequent activation is inhibited by vaccinia virus protein E3.
TRAF6-mediated ubiquitination is required for IRF7 activation.
Similarity:
Belongs to the IRF family.
Contains 1 IRF tryptophan pentad repeat DNA-binding domain.
SWISS:
Q92985
Gene ID:
3665
Database links:
Entrez Gene: 3665 Human
Entrez Gene: 54123 Mouse
Entrez Gene: 293624 Rat
Omim: 605047 Human
SwissProt: Q92985 Human
SwissProt: P70434 Mouse
Unigene: 166120 Human
Unigene: 3233 Mouse
Unigene: 101159 Rat
热门标签：磷酸化干扰素调节因子7抗体,雅吉抗体,一抗
