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小鼠海马神经元高分论文
点击次数：1076发布时间：2019/11/28 9:36:29
Fully simulating the components ａnd microstructures of soft tissue is a
challenge for its functional regeneration. A new aligned hydrogel microfiber
scaffold for spinal cord regeneration is constructed with photocrosslinked gelatin
methacryloyl (GelMA) ａnd electrospinning technology
. The directional porous
hydrogel fibrous scaffold consistent with nerve axons is vital to guide cell
migration ａnd axon extension. The GelMA hydrogel electrospun fibers soak up
water more than six times their weight, with a lower Young
’
s modulus, providing
a favorable survival ａnd metabolic environment for neuronal cells. GelMA fibers
further demonstrate higher antinestin, anti
-
Tuj
-
1, antisynaptophysin, ａnd
anti
-
CD31 gene expression in neural stem cells, neuronal cells, synapses, ａnd
vascular endothelial cells, respectively
. In contrast, anti
-
GFAP ａnd anti
-
CS56
labeled astrocytes ａnd glial scars of GelMA fibers are shown to be present in a
lesser extent compared with gelatin fibers. The soft bionic scaffold constructed
with electrospun GelMA hydrogel fibers not only facilitates the migration of
neural stem cells ａnd induces their differentiation into neuronal cells, but also
inhibits the glial scar formation ａnd promotes angiogenesis. Moreover, the scaf
fold with a high degree of elasticity can resist deformation without the protec
tion of a bony spinal canal. The bioinspired aligned hydrogel microfiber proves to
be efficient ａnd versatile in triggering functional regeneration of the spinal cord.
DOI: 10.1002/adfm.201806899
to be more prone to favor the reconstruc
tion of damaged tissues, as well as the
restoration of corresponding functionality
.
Yet, significant challenges still remain on
the regenerative engineering of certain
intricate tissue
-
based architectures. As a
component of the central nervous system
(CNS), spinal cord not only plays a crucial
role in the maintenance of vital signs, but
also preserves the proper functioning of
motion ａnd sensory system. Hence, injury
of this delicate cord could significantly
compromise the general health condition
of patients, inevitably leading to consid
erable social
-
economic burdens.[4] Unfor
tunately, although numerous attempts
have been made to reconstruct the injured
spinal cord, ideal outcome was still out
of reach. Intrinsically poor regenerative
capacity of the spinal cord, along with its
complex innate structure, were believed to
be responsible for the dilemma.[5] Soaked
in cerebrospinal fluid (CSF) ａnd protected
by the bony structure of the spinal canal,
the spinal cord consists of numerous
ascending ａnd descending nerve conduction bundles reached
out from highly differentiated neurons, which act as the signal
connection between the different segments of this structure
and the brain.[3] Based on the physiological ａnd anatomical
characteristics of the spinal cord, the corresponding biological
