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技术文章
文献引用产品|RMa-bm大鼠巨噬细胞
点击次数：460 发布时间：2026/8/10 10:23:57
文章标题：Janus sponge/electrospun fibre composite combined with EGF/bFGF/CHX promotes reconstruction in oral tissue regeneration
影响因子：5.4
期刊：COLLOIDS AND SURFACES B-BIOINTERFACES
作者列表：Xiaoli Lu, Shangwen Sun, Na Li, Shuying Hu, Yuyao Pan, Lin Wang, Xuefeng Zhou, Hanbang Chen, Feimin Zhang
发表时间：2024-7-22
DOI:10.1007/s40618-022-01998-x
主要研究成果：Abstract
Guided bone regeneration （GBR） is currently the most widely used bone augmentation technique in oral clinics. However, infection ａnd soft tissue management remain the greatest challenge. In this study, a Janus sponge/electrospun fibre membrane containing epidermal growth factor （EGF）, basic fibroblast growth factor （bFGF） ａnd chlorhexidine （CHX） were prepared to optimize its application as a barrier membrane for GBR. The loose sponge part was covalently bonded with the fiber part which has a dense structure. The composed scaffold exhibited superior biocompatibility ａnd antibacterial activity verified by in vitro test. A rat model of unilateral skull bone injury was used to confirm the effectiveness on both hard ａnd soft tissue regeneration. The chitosan sponge on the soft tissue side containing EGF, bFGF ａnd CHX had a loose structure, promoting collagen ａnd cell regeneration ａnd exerting an antibacterial effect. Meanwhile, the dense PLGA/PCL ｌayer on the hard tissue side prevented fibroblast entry into the bone defect, thereby facilitating bone regeneration. The Janus composite scaffold provides a promising strategy for oral tissue restoration.
原创作者：上海雅吉生物科技有限公司
