企业档案
会员类型：旗舰版
已获得阿仪网信誉 等级评定
(0 -40)基础信誉积累，可浏览访问
(41-90)良好信誉积累，可接洽商谈
(91+ )优质信誉积累，可持续信赖
阿仪网旗舰版会员：9年
工商认证 【已认证】
最后认证时间：
注册号： 【已认证】
法人代表： 【已认证】
参观次数：7948944
手机网站：http://wap.app17.com/c137908/
旗舰版网址：http://www.yajiml.com
技术文章
文献引用产品：猪肿瘤坏死因子α（TNF-α）Elisa试剂盒
点击次数：709 发布时间：2026/6/18 13:17:26
文章标题：Lysozyme improves gut perｆormance and protects against enterotoxigenic Escherichia coli infection in neonatal piglets
作者列表：Huang Guangping, Li Xiangqing, Lu Dan, Liu Shen, Suo Xun, Li Qiuyan, Li Ning
影响因子：2.903
期刊：VETERINARY RESEARCH
发表时间：2018-2-20
DOI:10.1186/s13567-018-0511-4
文献主题：Abstract
Diarrhea remains one of the leading causes of morbidity and mortality globally, with enterotoxigenic Escherichia coli (ETEC) constituting a major causative pathogen. The development of alternative treatments for diarrhea that do not involve chemotherapeutic drugs or result in antibiotic resistance is critical. Considering that lysozyme is a naturally occurring antimicrobial peptide, in a previous study we developed a transgenic pig line that expresses recombinant human lysozyme (hLZ) in its milk. In the present study, we examined the protective effects of the consumption of this milk against ETEC infection in neonatal piglets. We found that consuming hLZ milk facilitated faster recovery from infection and decreased mortality and morbidity following an ETEC oral inoculation or infection acquired by contact-exposure. The protective effect of hLZ was associated with the enrichment of intestinal bacteria that improve gut health, such as Lactobacillus, and the enhancement of the mucosal IgA response to the ETEC-induced diarrhea. Our study revealed potential protective mechanisms underlying the antimicrobial activity of human lysozyme, validating the use of lysozyme as an effective preventive measure for diarrhea.
原创作者：上海雅吉生物科技有限公司
