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文献引用产品|GOS-3（人胶质细胞细胞）
点击次数：712 发布时间：2026/6/12 13:13:51
文章标题：microRNA-155-3p delivered by M2 macrophages-derived exosomes enhances the progression of medulloblastoma through regulation of WDR82
影响因子：8.44
期刊：Journal of Translational Medicine
作者列表：Song Li, Luan Bin, Xu Qingrong, Shi Ruihe, Wang Xiufang
发表时间：2022-1-4
DOI:10.1186/s12967-021-03156-y
主要研究成果：Objective
Exosomes, membranous nanovesicles, naturally bringing proteins, mRNAs, and microRNAs (miRNAs), play crucial roles in tumor pathogenesis. This study was to investigate the role of miR-155-3p from M2 macrophages-derived exosomes (M2-Exo) in promoting medulloblastoma (MB) progression by mediating WD repeat domain 82 (WDR82).
Methods
miR-155-3p expression was detected by RT-qPCR. The relationship of miR-155-3p with clinicopathological features of MB patients was analyzed. M2-Exo were isolated and identified by TEM, NTA and Western blot. CCK-8 assay, colony ｆormation assay, flow cytometry, wound healing assay, and Transwell assay were perｆormed to explore the role of miR-155-3p-enriched M2-Exo on the progression of MB cells. Luciferase assay were used to identify the relationship between miR-155-3p and WDR82. The effect of miR-155-3p-enriched M2-Exo on tumorigenesis of MB was confirmed by the xenograft nude mice model.
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论文网址：https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-021-03156-y
原创作者：上海雅吉生物科技有限公司
