企业档案
会员类型：旗舰版
已获得阿仪网信誉 等级评定
(0 -40)基础信誉积累，可浏览访问
(41-90)良好信誉积累，可接洽商谈
(91+ )优质信誉积累，可持续信赖
阿仪网旗舰版会员：9年
工商认证 【已认证】
最后认证时间：
注册号： 【已认证】
法人代表： 【已认证】
参观次数：7948944
手机网站：http://wap.app17.com/c137908/
旗舰版网址：http://www.yajiml.com
技术文章
文献引用产品：HepaRG人肝癌细胞
点击次数：934 发布时间：2026/4/15 16:55:20
文章标题：DNASE1L3 Mediates Hepatocellular Carcinoma Tumor Growth and Organoid Models via the Wnt/β-Catenin Signaling Pathway
作者列表：Shulong Zhang, Yijun Zhao, Li Geng, Feihong Song, Li Feng, Jun Jiang, Qianqian Cai, Fei Fan
发表时间：2026-2-24
期刊：ONCOLOGY RESEARCH
影响因子：4.1
DOI:10.1038/s41419-021-04210-9
主要研究成果：Abstract
Background
Hepatocellular carcinoma (HCC) is a highly lethal malignancy driven by both intrinsic oncogenic pathways and immune microenvironmental regulation. Emerging evidence suggests that DNASE1L3 may influence tumor biology and immune responses; however, its specific roles in HCC progression and macrophage-mediated regulation remain unclear. This study aimed to elucidate the biological functions of DNASE1L3 in HCC and to determine how it modulates tumor behavior and immune interactions.
Methods
Bioinｆormatics analyses of the GSE41804 and Cancer Genome Atlas-Liver Hepatocellular Carcinoma (TCGA-LIHC) datasets were used to identify hub genes. Functional assays assessed the impact of DNASE1L3 on HCC cell proliferation, migration, invasion, and cell cycle progression. The effects of DNASE1L3 on macrophage polarization and the Wnt/β-catenin signaling pathway were examined using a co-culture system. An HCC organoid model was established to further validate its regulatory function.
原创作者：上海雅吉生物科技有限公司
