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技术文章
文献引用产品：人宫颈癌细胞CaSKi
点击次数：998 发布时间：2026/4/15 16:54:19
文章标题：Exogenous Na2SiO3 Mitigates the Adverse Effects of Drought Stress on Cucumber Seed Germination by Regulating the AsA-GSH Cycle
作者列表：Kexin Chen, Zitong Liu, Xin Meng, Shuyan Jiang, Li Jin, Shuya Wang, Shuchao Huang, Jian Lyu, Ning Jin, Jihua Yu
发表时间：2026-2-18
期刊：Horticulturae
影响因子：3
DOI:10.3390/horticulturae12020243
主要研究成果：Abstract
Cervical cancer (CC) remains a significant global health burden despite advances in prevention and screening. Emerging evidence highlights the critical role of long non-coding RNAs (lncRNAs) and RNA modifications in tumorigenesis. Here, we identified LINC01094 as a highly expressed lncRNA in CC through TCGA analysis and clinical specimens. Functional studies, including CCK-8 method, flow cytometry, Transwell and Western blot assays, demonstrated that LINC01094 knockdown suppressed cell proliferation, migration, and epithelial-mesenchymal transition while promoting apoptosis in CC cells (Caski and SiHa). Mechanistically, NSUN2-mediated 5-methylcytosine methylation stabilized LINC01094, enhancing its expression in CC. Furthermore, LINC01094 facilitated ZNF582-dependent tranｓcriptional activation of SIRT1, promoted the deacetylation and degradation of p53. Rescue experiments confirmed that ectopic expression of either LINC01094 or SIRT1 reversed the tumor-suppressive effects of NSUN2 or LINC01094 knockdown, respectively. Collectively, NSUN2-mediated stabilization of LINC01094 upregulated SIRT1 expression, thereby suppressing the p53 pathway and accelerating CC progression. These findings uncover a novel NSUN2/LINC01094/SIRT1 axis as an epigenetic-tranｓcriptional driver of CC, offering potential therapeutic targets.
原创作者：上海雅吉生物科技有限公司
