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技术文章
文献引用产品：小鼠肝癌细胞Hepa1-6
点击次数：1006 发布时间：2026/3/25 15:42:50
文章标题：DTX2 attenuates Lenvatinib-induced ferroptosis by suppressing docosahexaenoic acid biosynthesis through HSD17B4-dependent peroxisomal β-oxidation in hepatocellular carcinoma
期刊：DRUG RESISTANCE UPDATES
作者列表：Zhongyan Zhang, Qi Zhou, Zhenchong Li, Fuxin Huang, Ke Mo, Cheng Shen, Xing Niu, Baohua Hou, Chuanzhao Zhang, Shanzhou Huang
发表时间：2025-2-28
影响因子：21.7
DOI:10.1016/j.drup.2025.101224
主要研究成果：Abstract
Aims
Emerging resistance to Lenvatinib, which is used as a first-line agent for the treatment of advanced hepatocellular carcinoma (HCC), is still a concern. The aim of this study was to determine core factors of Lenvatinib resistance (LR) and their underlying molecular mechanisms.
Methods
CRISPR screening in HCC cells was conducted, which identified E3 ubiquitin ligase deltex 2 (DTX2) as a core LR-related gene. In vivo and in vitro models were used to clarify the function of DTX2 on LR and ferroptosis. The upstream regulators and downstream effectors of DTX2 were identified, revealing its complex regulatory network.
原创作者：上海雅吉生物科技有限公司
