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技术文章
文献引用产品：Enhanced Cell Counting Kit-8 （增强型CCK-8试剂盒）
点击次数：1058 发布时间：2026/3/12 16:44:01
文章标题：Cellulose fibers-reinforced self-expanding porous composite with multiple hemostatic efficacy and shape adaptability for uncontrollable massive hemorrhage treatment
作者列表：Yansen Wang, Yifan Zhao, Longxue Qiao, Faxing Zou, Yajie Xie, Yudong Zheng, Yong Chao, Ying Yang, Wei He, Siming Yang
期刊：Bioactive Materials
发表时间：2021-1-11
影响因子：14.593
DOI:10.1016/j.bioactmat.2020.12.014
主要研究成果：Abstract
Uncontrollable hemorrhage leads to high mortality and thus effective bleeding control becomes increasingly important in the military field and civilian trauma arena. However, current hemostats not only present limitation when treating major bleeding, but also have various side effects. Here we report a self-expanding porous composites (CMCP) based on novel carboxymethyl cellulose (CMC) fibers and acetalized polyvinyl alcohol (PVA) for lethal hemorrhage control. The CMC fibers with uniｆorm fibrous structure, high liquid absorption and procoagulant ability, are evenly interspersed inside the composite matrix. The obtained composites possess unique fiber-porous network, excellent absorption capacity, fast liquid-triggered self-expanding ability and robust fatigue resistance, and their physicochemical perｆormance can be fine-tuned through varying the CMC content. In vitro tests show that the porous composite exhibits strong blood clotting ability, high adhesion to blood cells and protein, and the ability to activate platelet and the coagulation system. In vivo hemostatic evaluation further confirms that the CMCP presents high hemostatic efficacy and multiple hemostatic effects in swine femoral artery major hemorrhage model. Additionally, the CMCP will not fall off from the injury site, and is also easy to surgically remove from the wound cavity after the hemostasis. Importantly, results of CT tomography and 3D reconstruction indicate that CMCP can achieve shape adaptation to the surrounding tissues and the wound cavities with different depths and shapes, to accelerate hemostasis while protecting wound tissue and preventing infection.
原创作者：上海雅吉生物科技有限公司
