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技术文章
文献引用产品：SKOV3人卵巢腺瘤细胞
点击次数：1394 发布时间：2025/12/22 9:52:59
文章标题：Zinc oxide nanoparticles mitigate the malignant progression of ovarian cancer by mediating autophagy-dependent ferroptosis
期刊：JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
作者列表：Gu Wenli, Yang Caihong
发表时间：2024-11-27
影响因子：2.7
DOI:10.1007/s00432-024-06029-1
主要研究成果：Abstract
Background
Previous studies have shown that ZnO-NPs induce autophagy ａnd inhibit the malignant progression of ovarian cancer （OC） cells. This study aims to further explore the mechanism of action of ZnO-NPs on OC.
Methods
SKOV3 cells were treat with different concentrations of ZnO-NPs ａnd cell proliferation was assessed through EDU staining. A Xenograft tumor model was established ａnd mice were treated with varying doses of ZnO-NPs for 21 days. Tumor volume ａnd the weight of each group of mice were measured, ａnd the expression of KI67 in tumor tissues was analyzed to evaluate tumor proliferation in vivo. The expression of autophagy ａnd ferroptosis-related proteins in cells ａnd tumor tissues was examined through immunofluorescence, ELISA, ａnd western blotting assays. The relationship between ZnO-NPs induced autophagy ａnd ferroptosis was further investigated using the ferroptosis inhibitors Fer-1, autophagy inhibitor 3-MA ａnd siRNA for ATG5 （si-ATG5）.
原创作者：上海雅吉生物科技有限公司
