转录下调蛋白1抗体简介说明_资料下载_上海岑特生物科技有限公司

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转录下调蛋白1抗体简介说明

点击次数： 46发布时间：2022/3/29 14:10:52

上传者：昆山远慕生物科技有限公司
上传时间： 2022/3/29 14:10:52
文件大小： 15KB
文件类型： docx
所属分类：应用方法
下载次数： 3次
查看次数： 46

资料简介：

英文名称 DR1 protein

中文名称转录下调蛋白1抗体

别名 Dr1 protein; NC2; Negative cofactor 2 beta; Down regulator of transcription 1; Down regulator of transcription 1 TBP binding; Down-regulator of transcription 1; DR 1; Dr1; NC 2; NC2 beta; NC2-beta; NC2B_HUMAN; Negative co factor 2; Negative cofactor 2; Negative cofactor 2-beta; Protein Dr1; TATA binding protein associated phosphoprotein; TATA-binding protein-associated phosphoprotein.

供应商远慕生物

研究域细胞生物免疫学转录调节因子表观遗传学

抗体来源 Rabbit

克隆类型 Polyclonal

交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Horse,

产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:20-100 IF=1:50-200 转录下调蛋白1抗体（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.

分子量 19kDa

细胞定位细胞核

性状 Lyophilized or Liquid

浓度 1mg/1ml

免疫原 KLH conjugated synthetic peptide derived from human DR1 protein

亚型 IgG

纯化方法 affinity purified by Protein A

储存液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

转录下调蛋白1抗体产品介绍 background:

DR1, also known as NC2∫ (negative cofactor 2 subunit ∫), is a TFIID (TATA box-binding protein)-associated protein. DR1 localizes to the nucleus ａnd contains an N-terminal histone fold motif, a TFIID-binding domain ａnd an alanine ａnd glutamine rich region. Via its histone fold motif, DR1 forms a heterodimer with NC2? (DRAP1) to comprise the conserved eukaryotic complex, NC2 (negative cofactor 2). The NC2 complex can both positively ａnd negatively regulate transcription by RNA Pol II. More specifically, NC2 acts as a repressor of TATA-dependent transcription ａnd acts as an activator for DPE-dependent transcription. NC2 represses RNA Pol II transcription by binding to TFIID ａnd inhibiting association of the transcription factors TFIIA ａnd TFIIB. NC2 activity is regulated by phosphorylation. Both subunits, NC2? ａnd DR1, are phosphorylated in vivo.

Function:
The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated ａnd basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 ａnd H4.

Subunit:
Heterodimer with DRAP1. DR1 exists in solution as a homotetramer that dissociates during interaction with TBP ａnd then, after complexing with TBP, reassociates at a slow rate, to reconstitute the tetramer. Interacts with NFIL3. Component of the ADA2A-containing complex (ATAC), composed of CSRP2BP, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 ａnd DR1.

Subcellular Location:
Nucleus.

Post-translational modifications:
Phosphorylation regulates its interaction with TBP. Not phosphorylated when bound to DRAP1.

Similarity:
Belongs to the NC2 beta/DR1 family.
Contains 1 histone-fold domain.

转录下调蛋白1抗体

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生物分子

ELISA试剂盒

液体试剂

生化试剂

标准品/对照品

抗体

培养基

动物血清/细胞

PCR检测试剂盒

实验耗材

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