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有丝分裂控制样蛋白DIS3L抗体产品介绍
点击次数： 56发布时间：2022/3/29 13:59:55
- 上 传 者： 昆山远慕生物科技有限公司
- 上传时间： 2022/3/29 13:59:55
- 文件大小： 14KB
- 文件类型： docx
- 所属分类： 应用方法
- 下载次数： 3次
- 查看次数： 56
资料简介： 英文名称 DIS3L 中文名称 有丝分裂控制样蛋白DIS3L抗体 别 名 DIS3 like exonuclease 1; DIS3 mitotic control homolog (S. cerevisiae) like; FLJ38088; KIAA1955; MGC4562; DI3L1_HUMAN. 供 应 商 远慕生物 研究域 细胞生物 免疫学 表观遗传学 抗体来源 Rabbit 克隆类型 Polyclonal 交叉反应 Human, Mouse, Rat, Pig, Horse, 产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复）有丝分裂控制样蛋白DIS3L抗体 分 子 量 121kDa 细胞定位 细胞浆 性 状 Lyophilized or Liquid 浓 度 1mg/1ml 免 疫 原 KLH conjugated synthetic peptide derived from human DIS3L 亚 型 IgG 纯化方法 affinity purified by Protein A 储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4 保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 有丝分裂控制样蛋白DIS3L抗体产品介绍 background: The exosome is a multi-protein complex composed of several highly conserved subunits, some of which are 3’ to 5’ exoribonucleases. The complex is involved in a variety of cellular processes ａnd is responsible for degrading unstable mRNAs that contain AU-rich elements (AREs) in their untranslated 3’ regions. DIS3, also known as RRP44, is a 958 amino acid protein that localizes to both the cylasm ａnd the nucleus ａnd contains one PINc domain. Widely expressed with highest expression in testis, DIS3 functions as a component of the exosome exoribonuclease complex ａnd is required for processing of 7S pre-RNA into a mature nuclear complex and, ultimately, for proper mitotic progression. Abnormal expression levels of DIS3 may be associated with colon cancer, suggesting a role for DIS3 in tumorigenesis. Multiple isoforms of DIS3 exist due to alternative splicing events. Function: Subunit: Subcellular Location: Similarity:
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
Putative cylasm-specific catalytic component of the RNA exosome complex which has 3＇->5＇ exoribonuclease activity ａnd participates in a multitude of cellular RNA processing ａnd degradation events. In the cylasm, the RNA exosome complex is involved in general mRNA turnover ａnd specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3＇ untranslated regions, ａnd in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA.
Component of the RNA exosome complex. The catalytically inactive RNA exosome core (Exo-9) complex is believed to associate with catalytic subunits EXOSC10, ａnd DIS3 or DIS3L in cylasmic-and nuclear-specific RNA exosome complex forms.
Cylasm.
Belongs to the RNR ribonuclease family.
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