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动力结合蛋白DNMBP抗体应用说明
点击次数： 66发布时间：2022/3/22 14:40:04
- 上 传 者： 昆山远慕生物科技有限公司
- 上传时间： 2022/3/22 14:40:04
- 文件大小： 14KB
- 文件类型： docx
- 所属分类： 应用方法
- 下载次数： 3次
- 查看次数： 66
资料简介： 英文名称 Anti-DNMBP 动力结合蛋白DNMBP抗体产品介绍 DNMBP, also known as Scaffold protein TUBA, is a 1,577 amino acid protein that localizes to a variety of locations within the cell, including the cylasm, cytoskeleton, cell junction ａnd Golgi apparatus, ａnd contains one BAR domain, one DH domain ａnd six SH3 domains. Expressed in kidney, heart, lung, liver, brain, pancreas ａnd skeletal muscle, Tuba functions as a scaffold protein that links Dynamin with Actin-regulating proteins ａnd is thought to play a role in protein trafficking between the golgi ａnd the cell surface. Two isoforms of Tuba exist due to alternative splicing events. The gene encoding Tuba maps to human chromosome 10, which houses over 1,200 genes ａnd comprises nearly 4.5% of the human genome. Defects in some of the genes that map to chromosome 10 are associated with Charcot-Marie Tooth disease, Jackson-Weiss syndrome, Usher syndrome, nonsyndromatic deafness, Wolman’s syndrome, Cowden syndrome, multiple endocrine neoplasia type 2 ａnd porphyria.
中文名称 动力结合蛋白DNMBP抗体
别 名 Dnmbp; DNMBP_HUMAN; Dynamin binding protein; Dynamin-binding protein; KIAA1010; Scaffold protein TUBA; TUBA.
公司动力结合蛋白DNMBP抗体应用于医学免疫学、动物免疫学、分子生物学、生物化学、临床医学、检验医学、动物医学、药学、理工、农学、环境学等生命科学密切相关的业。
浓 度 1mg/1ml
规 格 0.2ml/200μg
抗体来源 Rabbit
克隆类型 polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Sheep
产品类型 一抗
研究域 肿瘤 细胞生物 免疫学
蛋白分子量 predicted molecular weight: 177kDa
性 状 Lyophilized or Liquid
免 疫 原 KLH conjugated synthetic peptide derived from human DNMBP
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Function : Scaffold protein that links dynamin with actin-regulating proteins. May play a role in membrane trafficking between the cell surface ａnd the Golgi (By similarity).
Subunit : Binds DNM1 via its N-terminal SH3 domains. The C-terminal SH3 domain binds a complex containing actin, tubulin, Hsp70 ａnd actin-regulatory proteins, such as ENAH, EVL, WASL, WIRE, CR16, WAVE1 ａnd NAP1L1 (By similarity). Interacts with FASLG.
Subcellular Location : Cylasm (By similarity). Golgi apparatus, Golgi stack (By similarity). Cylasm, cytoskeleton (By similarity). Cell junction, synapse (By similarity). Note=Localized to synapses ａnd Golgi stacks (By similarity).
Tissue Specificity : Detected in heart, brain, lung, liver, skeletal muscle, kidney ａnd pancreas.
Similarity : Contains 1 BAR domain.
Contains 1 DH (DBL-homology) domain.
Contains 6 SH3 domains.
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