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资料下载
DEPTOR蛋白抗体应用方法
点击次数： 58发布时间：2022/3/15 15:30:54
- 上 传 者： 昆山远慕生物科技有限公司
- 上传时间： 2022/3/15 15:30:54
- 文件大小： 13KB
- 文件类型： docx
- 所属分类： 操作维修手册
- 下载次数： 2次
- 查看次数： 58
资料简介： 中文名称：DEPTOR蛋白抗体 DEPTOR蛋白抗体产品介绍 background: Function: Subunit: Post-translational modifications:
英文名称：DEPTOR
别名：DEP domain containing 6; DEP domain-containing mTOR-interacting protein; DEP domain-containing protein 6; DEPDC6; DEPTOR; DPTOR_HUMAN.
规格：0.2ml
研究域：肿瘤细胞生物免疫学神经生物学细胞凋亡
抗体来源：Rabbit
克隆类型：Polyclonal
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit,
产品应用：WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 DEPTOR蛋白抗体（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量：46kDa
性状：Lyophilized or Liquid
浓度：1mg/1ml
免 疫 原：KLH conjugated synthetic peptide derived from human DEPTOR/DEPDC6
亚型：IgG
纯化方法：affinity purified by Protein A
储 存 液：Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存条件：Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
DEPTOR (DEP domain containing MTOR-interacting protein), also known as DEP.6 or DEPDC6 (DEP domain-containing protein 6), is a 409 amino acid protein that negatively regulates mTORC1 ａnd mTORC2 pathways. DEPTOR interacts with FRAP via its PDZ domain, ａnd undergoes post-translational phosphorylation. Containing two DEP domains ａnd one PDZ (DHR) domain, DEPTOR is encoded by a gene that maps to human chromosome 8q24.12. Chromosome 8 consists of nearly 146 million base pairs, encodes over 800 genes ａnd is associated with a variety of diseases ａnd malignancies. Schizophrenia, bipolar disorder, Trisomy 8, Pfeiffer syndrome, congenital hypothyroidism, Waardenburg syndrome ａnd some leukemias ａnd lymphomas are thought to occur as a result of defects in specific genes that map to chromosome 8.
Negative regulator of the mTORC1 ａnd mTORC2 signaling pathways. Inhibits the kinase activity of both complexes.
Part of the mammalian target of rapamycin complex 1 (mTORC1) which contains MTOR, MLST8, RPTOR, AKT1S1/PRAS40 ａnd DEPTOR. Part of the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PROTOR1, RICTOR, MAPKAP1 ａnd DEPTOR. Interacts (via PDZ domain) with MTOR; interacts with MTOR within both mammalian target of rapamycin complexes mTORC1 ａnd mTORC2.
Phosphorylated. Phosphorylation weakens interaction with MTOR within mTORC1 ａnd mTORC2.
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