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DENND1B蛋白抗体简介说明
点击次数： 49发布时间：2022/3/9 15:37:35
- 上 传 者： 昆山远慕生物科技有限公司
- 上传时间： 2022/3/9 15:37:35
- 文件大小： 14KB
- 文件类型： docx
- 所属分类： 操作维修手册
- 下载次数： 2次
- 查看次数： 49
资料简介： 英文名称 DENND1B Tissue specificity:Highly expressed in dendritic ａnd natural killer cells ａnd at lower levels in other myeloid lineage cells ａnd in pituitary. Significantly up-regulated in effector memory T cells as compared with naive T cells. Function: Subunit: Subcellular Location: Tissue Specificity: Post-translational modifications:
中文名称 DENND1B蛋白抗体
别 名 C1ORF18; C1orf218; Chromosome 1 open reading frame 218; Connecdenn 2; DEN1B_HUMAN; DENN domain containing protein 1B; DENN domain-containing protein 1B; DENN MADD domain containing 1B; DENND1B; DKFZp547O0715; FAM31B; Family with sequence similarity 31 member B; FLJ20054; FLJ21179; FLJ33888; MGC103810; MGC27044; Protein FAM31B
说 明 书 0.2ml
研究域 细胞生物 免疫学
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Cow, Horse, Rabbit,
产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 DENND1B蛋白抗体（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 48kDa
细胞定位 细胞浆
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human DENND1B
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
DENND1B蛋白抗体产品介绍 background:
Guanine nucleotide exchange factor (GEF) for RAB35. May function as a clathrin-associated sorting protein for RAB35, whereby during clathrin-mediated endocytosis, binds the AP-2 complex ａnd inactived RAB35, then activates RAB35 for its subsequent function at endosomes.
Guanine nucleotide exchange factor (GEF) for RAB35. May function as a clathrin-associated sorting protein for RAB35, whereby during clathrin-mediated endocytosis, binds the AP-2 complex ａnd inactivates RAB35, then activates RAB35 for its subsequent function at endosomes.
Interacts with RAB35 in the absence of nucleotide, but not in the presence of GTP. Interacts with clathrin heavy chain/CLTC ａnd with AP2A2. Isoform 5 interacts with AP2B1.
Cylasm, cytosol. Cylasmic vesicle, clathrin-coated vesicle.
Highly expressed in dendritic ａnd natural killer cells ａnd at lower levels in other myeloid lineage cells ａnd in pituitary. Significantly up-regulated in effector memory T-cells as compared with naive T-cells.
Isoform 5 is phosphorylated on Tyr-475, Tyr-484, Ser-514 ａnd Ser-652.
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