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DULLARD蛋白抗体说明书
点击次数： 61发布时间：2022/1/17 15:16:10
- 上 传 者： 昆山远慕生物科技有限公司
- 上传时间： 2022/1/17 15:16:10
- 文件大小： 15KB
- 文件类型： docx
- 所属分类： 操作维修手册
- 下载次数： 12次
- 查看次数： 61
资料简介： 产品名称：DULLARD蛋白抗体 别名：Dullard homolog; HSA 011916; NET 56 antibodySerine threonine protein phosphatase dullard; CNEP1_HUMAN. 浓度：1mg/1ml 规格：0.2ml/200μg 抗体来源：Rabbit 克隆类型：polyclonal 交叉反应：Human, Mouse, Rat, Dog, Cow, Horse 产品类型：DULLARD蛋白抗体一抗 研究域：神经生物学 信号转导 激酶和磷酸酶 表观遗传学 蛋白分子量：predicted molecular weight: 28kDa 性状：Lyophilized or Liquid 免疫原：KLH conjugated synthetic peptide derived from human DULLARD 亚型：IgG 纯化方法：affinity purified by Protein A 储存液：Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4 产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 保存条件：Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 产品介绍：In eukaryotes, the phosphorylation ａnd dephosphorylation of proteins on serine ａnd threonine residues is an essential means of regulating a broad range of cellular functions, including division, homeostasis ａnd apoptosis. A group of proteins that are intimately involved in this process are the protein phosphatases. Dullard, also known as NET56, is a 244 amino acid single-pass membrane protein that localizes to both the nucleus ａnd the endoplasmic reticulum ａnd contains one FCP1 homology domain. Functioning as a serine/threonine phosphatase, Dullard catalyses the dephosphorylation of target proteins ａnd is thought to be required for proper nuclear membrane morphology. Human Dullard shares 92% sequence identity with its zebrafish counterpart, suggesting a conserved role between species. Function : DULLARD is a serine/threonine phosphatase which may be required for proper nuclear membrane morphology. It is involved in LPIN1 dephosphorylation ａnd may antagonize BMP signaling. Subunit : Interacts with CNEP1R1; the complex dephosphorylates LPIN1 ａnd LPIN2. Subcellular Location : Endoplasmic reticulum membrane; Single-pass membrane protein. Nuclear membrane; Single-pass membrane protein. Tissue Specificity : Muscle specific with lower expression in other metabolic tissues. Similarity : Belongs to the dullard family. Contains 1 FCP1 homology domain. Database links : UniProtKB/Swiss-Prot: O95476.2
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
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