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磷酸化信号转导功能磷蛋白DAB2抗体简介说明
点击次数： 79发布时间：2021/12/31 15:02:17
- 上 传 者： 上海古朵生物科技有限公司
- 上传时间： 2021/12/31 15:02:17
- 文件大小： 15KB
- 文件类型： docx
- 所属分类： 应用方法
- 下载次数： 7次
- 查看次数： 79
资料简介： 中文名称 磷酸化信号转导功能磷蛋白DAB2抗体 磷酸化信号转导功能磷蛋白DAB2抗体产品介绍 background: DAB2 is a component of the CSF1 signal transduction pathway. DAB2 mRNA is expressed in normal ovarian epithelial cells but is down regulated or absent from ovarian carcinoma cell lines. The down regulation of DAB2 may play an important role in ovarian carcinogenesis. This gene was initially named DOC2 (for Differentially expressed in Ovarian Cancer) ａnd is distinct from the DOC2A ａnd DOC2B genes (for double C2 like domains, alpha ａnd beta). Function: Subunit: Subcellular Location: Tissue Specificity: Post-translational modifications: Similarity:
英文名称 phospho-DAB2 (Ser24)
别 名 p-Dab2(Ser24); DAB 2; DAB-2; Differentially expressed protein 2; Disabled (Drosophila) homolog 2 (mitogen responsive phosphoprotein); disabled (Drosophila) homolog 2 (mitogen-responsive phosphoprotein); Disabled homolog 2; Disabled homolog 2 mitogen responsive phosphoprotein (Drosophila); Disabled homolog 2 mitogen responsive phosphoprotein; disabled homolog 2 mitogen-responsive phosphoprotein (Drosophila); DOC 2; DOC2; FLJ26626; Mitogen responsive phosphoprotein; DAB2_HUMAN.
规 格 0.1ml
产品类型 磷酸化抗体
研究域 肿瘤 细胞生物 信号转导 细胞周期蛋白 转录调节因子 激酶和磷酸酶 表观遗传学
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow,
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 磷酸化信号转导功能磷蛋白DAB2抗体（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 85kDa
细胞定位 细胞浆 细胞膜
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthesised phosphopeptide derived from human DAB2 around the phosphorylation site of Ser24 [AP(p-S)KK]
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Adapter protein that functions as clathrin-associated sorting protein (CLASP) required for clathrin-mediated endocytosis of selected cargo proteins. Can bind ａnd assemble clathrin, ａnd binds simultaneously to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) ａnd cargos containg non-phosphorylated NPXY internalization motifs, such as the LDL receptor, to recruit them to clathrin-coated pits. Can function in clathrin-mediated endocytosis independently of the AP-2 complex. Involved in endocytosis of integrin beta-1; this function seems to redundant with the AP-2 complex ａnd seems to require DAB2 binding to endocytosis accessory EH domain-containing proteins such as EPS15, EPS15L1 ａnd ITSN1. Involved in endocytosis of cystic fibrosis transmembrane conductance regulator/CFTR. Involved in endocytosis of megalin/LRP2 lipoprotein receptor during embryonal development. Required for recycling of the TGF-beta receptor. Involved in CFTR trafficking to the late endosome. Involved in several receptor-mediated signaling pathways. Involved in TGF-beta receptor signaling ａnd facilitates phosphorylation of the signal transducer SMAD2. Mediates TFG-beta-stimulated JNK activation. May inhibit the canoniocal Wnt/beta-catenin signaling pathway by stabilizing the beta-catenin destruction complex through a competing association with axin preventing its dephosphorylation through protein phosphatase 1 (PP1). Sequesters LRP6 towards clathrin-mediated endocytosis, leading to inhibition of Wnt/beta-catenin signaling. May activate non-canonical Wnt signaling. In cell surface growth factor/Ras signaling pathways proposed to inhibit ERK activation by interrupting the binding of GRB2 to SOS1 ａnd to inhibit SRC by preventing its activating phosphorylation at ＇Tyr-419＇. Proposed to be involved in modulation of androgen receptor (AR) signaling mediated by SRC activation; seems to compete with AR for interaction with SRC. Plays a role in the CSF-1 signal transduction pathway. Plays a role in cellular differentiation. Involved in cell positioning ａnd formation of visceral endoderm (VE) during embryogenesis ａnd proposed to be required in the VE to respond to Nodal signaling coming from the epiblast. Required for the epithelial to mesenchymal transition, a process necessary for proper embryonic development. May be involved in myeloid cell differentiation ａnd can induce macrophage adhesion ａnd spreading. May act as a tumor suppressor.
Can interact (via PID domain) with LDLR, APP, APLP1 ａnd APLP2, ａnd weakly with INPP5D (via NPXY motifs); the interaction is impaired by tyrosine phosphorylation of the respective NPXY motifs. Can weakly interact (via PID domain) with LRP1 (via NPXY motif); the interaction is enhanced by tyrosine phosphorylation of the NPXY motif. Interacts with LRP2 (via NPXY motif); the interaction is not affected by tyrosine phosphorylation of the NPXY motif. Interacts with clathrin; in vitro can assemble clathrin triskelia into polyhedral coats. Interacts with AP2A2, ITGB1, ITGB3, ITGB5, PIAS2, DAB2IP, NOSTRIN, FCHO1, DVL3, EPS15, ITSN1 ａnd EPS15L1. Interacts with SH3KBP1 (via SH3 domains). Interacts with GRB2; competes with SOS1 for binding to GRB2 ａnd the interaction is enhanced by EGF ａnd NT-3 stimulation. Interacts with MAP3K7; the interaction is induced by TGF-beta stimulation ａnd may mediate TGF-beta stimulated JNK activation. Interacts with AXIN1 ａnd PPP1CA; the interactions are mutually exclusive. Interacts with the globular tail of MYO6. Interacts (via DPF motifs) with FCHO2; the interaction is direct ａnd required for DAB2-mediated LDLR endocytosis. Interacts with LRP6; the interaction involves LRP6 phosphorylation by CK2 ａnd sequesters LRP6 towards clathrin-mediated endocytosis. Associates with the TGF-beta receptor complex (Probable). Interacts with SMAD2 ａnd SMAD3; the interactions are enhanced upon TGF-beta stimulation. Interacts with GRB2; the interaction is enhanced by EGF ａnd NT-3 stimulation. Interacts with SRC; the interaction is enhanced by EGF stimulation.
Cylasmic vesicle; clathrin coated vesicle; clathrin coated vesicle membrane. Cell membrane; coated pit; clathrin coated pit. Note: Colocalizes with large ｉnsert containing isoforms of MYO6 at clathrin coated pits/vesicles.
Expressed in deep invaginations, inclusion cysts ａnd the surface epithelial cells of the ovary. Also expressed in breast epithelial cells, spleen, thymus, prostate, testis, macrophages, fibroblasts, lung epithelial cells, placenta, brain stem, heart ａnd small intestine. Expressed in kidney proximal tubular epithelial cells (at protein level).
Phosphorylated. Phosphorylation during mitosis is leading to membrane displacement (By similarity).
Contains 1 PID domain.
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