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含锚蛋白重复序列-细胞因子信号抑制物盒蛋白家族2抗体说明书
点击次数： 62发布时间：2021/12/24 15:22:27
- 上 传 者： 上海古朵生物科技有限公司
- 上传时间： 2021/12/24 15:22:27
- 文件大小： 15KB
- 文件类型： docx
- 所属分类： 应用方法
- 下载次数： 6次
- 查看次数： 62
资料简介： 中文名称 含锚蛋白重复序列-细胞因子信号抑制物盒蛋白家族2抗体 保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 含锚蛋白重复序列-细胞因子信号抑制物盒蛋白家族2抗体产品介绍 The ankyrin repeat ａnd SOCS box containing (ASB) protein family is comprised of members which each contain "SOCS boxes" but differ from other families of protein in the motifs they contain upstream of the SOCS box. SOCS boxes are carboxy terminal regions of homology found in the suppressor of cytokine signaling family of proteins. The box region is thought to be the point of interaction between SOCS proteins ａnd E3 ubiquitin ligases. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins ａnd their binding partners with the elongin B ａnd C complex, possibly targeting them for degradation. The gene is induced by all trans retinoic acid. In myeloid leukemia cells, the expression of this encoded protein has been shown to induce growth inhibition ａnd chromatin condensation. Multiple alternatively spliced transcript variants have been described for this gene but their full length sequences are not known. Function : Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination ａnd subsequent proteasomal degradation of target proteins Similarity : Contains 12 ANK repeats
别 名 Ankyrin repeat ａnd SOCS box 2 containing protein; Ankyrin repeat ａnd SOCS box containing 2; Ankyrin repeat ａnd SOCS box containing protein 2; Ankyrin repeat containing protein ASB2.ASB2_HUMAN
浓 度 1mg/1ml
规 格 0.2ml/200μg
抗体来源 Rabbit
克隆类型 polyclonal
交叉反应 Human, Mouse, Rat, Pig, Cow, Horse
产品类型 一抗
研究域 细胞生物 染色质和核信号 信号转导 细胞周期蛋白 转录调节因子 表观遗传学
蛋白分子量 predicted molecular weight: 65kDa
性 状 Lyophilized or Liquid
免 疫 原 KLH conjugated synthetic peptide derived from human Drebrin.
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA ａnd 0.1% Sodium azide
产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Subunit : Component of a probable ECS E3 ubiquitin-protein ligase complex which contains CUL5, either RBX1 or RNF7/RBX2, Elongin BC complex (TCEB1 ａnd TCEB2) ａnd ASB2
Contains 1 SOCS box domain.
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