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胞浆动力蛋白轻链1抗体使用方法
点击次数： 93发布时间：2021/12/20 15:48:06
- 上 传 者： 上海古朵生物科技有限公司
- 上传时间： 2021/12/20 15:48:06
- 文件大小： 15KB
- 文件类型： docx
- 所属分类： 操作维修手册
- 下载次数： 11次
- 查看次数： 93
资料简介： 英文名称 DYNLL1 胞浆动力蛋白轻链1抗体产品介绍 background: Function: Subunit: Subcellular Location:
中文名称 胞浆动力蛋白轻链1抗体
别 名 Cylasmic dynein light polypeptide; DLC1; DLC8; DNCL1; DNCLC1; DYL1_HUMAN; Dynein, cylasmic, light chain 1; Dynein light chain 1 cylasmic; Dynein light chain 1, cylasmic; Dynein light chain LC8 type 1; Dynein light chain LC8-type 1; Dynein, cylasmic, light polypeptide 1; Dynein, light chain, LC8-type 1; DYNLL1; HDLC1; LC8; LC8a; PIN; Protein inhibitor of neuronal nitric oxide synthase; Protein inhibitor of neuronal NOS; 8 kDa dynein light chain; 8kDLC.
规 格 0.2ml
研究域 肿瘤 细胞生物 免疫学 染色质和核信号 神经生物学 信号转导 细胞凋亡
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Pig, Cow, Horse, Rabbit,
产品应用 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 胞浆动力蛋白轻链1抗体not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 10kDa
细胞定位 细胞浆
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human Dynein light chain 1 cylasmic
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA ａnd 0.1% Sodium azide
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Cylasmic dyneins are large enzyme complexes with a molecular mass of about 1,200 kD. They contain two force-producing heads formed primarily from dynein heavy chains, ａnd stalks linking the heads to a basal domain, which contains a varying number of accessory intermediate chains. The complex is involved in intracellular transport ａnd motility. The protein described in this record is a light chain ａnd exists as part of this complex but also physically interacts with ａnd inhibits the activity of neuronal nitric oxide synthase. Binding of this protein destabilizes the neuronal nitric oxide synthase dimer, a conformation necessary for activity, ａnd it may regulate numerous biologic processes through its effects on nitric oxide synthase activity. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]
Acts as one of several non-catalytic accessory components of the cylasmic dynein 1 complex that are thought to be involved in linking dynein to cargos ａnd to adapter proteins that regulate dynein function. Cylasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles ａnd organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.
Binds ａnd inhibits the catalytic activity of neuronal nitric oxide synthase.
Promotes transactivation functions of ESR1 ａnd plays a role in the nuclear localization of ESR1.
Regulates apoptotic activities of BCL2L11 by sequestering it to microtubules. Upon apoptotic stimuli the BCL2L11-DYNLL1 complex dissociates from cylasmic dynein ａnd translocates to mitochondria ａnd sequesters BCL2 thus neutralizing its antiapoptotic activity.
Homodimer. Monomer; the monomeric form is incapable of binding to target proteins. The cylasmic dynein 1 complex consists of two catalytic heavy chains (HCs) ａnd a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) ａnd light chains (LCs); the composition seems to vary in respect to the IC, LIC ａnd LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs ａnd LICs bind directly to the HC dimer ａnd the LCs assemble on the IC dimer. Interacts with rabies P protein. Interacts with TXNDC17. Interacts with WWC1 ａnd ESR1. The WWC1-DYNLL1 interaction is mandatory for the recruitment ａnd transactivation functions of ESR1 or DYNLL1 to the target chromatin. Interacts with BCL2L11 isoform 1 ａnd isoform 2. Interacts with BCL2; the interaction is greatly enhanced in the nucleus ａnd in mitochondria upon induction of apoptosis. Interacts with PAK1; the interaction requires dimeric DYNLL1. Interacts with human spumaretrovirus Gag protein; this interaction is critical for intracellular microtubule-dependent viral genome transport toward the centrosome. Interacts with MYZAP. Part of an astrin (SPAG5)-kinastrin (SKAP) complex containing KNSTRN, SPAG5, PLK1, DYNLL1 ａnd SGOL2. Interacts with ATMIN; this interaction inhibits ATMIN transcriptional activity ａnd hence may play a role in a feedback loop whereby DYNLL1 inhibits transactivation of its own promoter by ATMIN. Interacts with NEK9 (not phosphorylated at ＇Ser-944＇).
Cylasm, cytoskeleton. Nucleus. Mitochondrion. Note=Upon induction of apoptosis translocates together with BCL2L11 to mitochondria.
Tissue Specificity:
Ubiquitous.
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