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无精症缺失基因1抗体产品介绍
点击次数： 65发布时间：2021/11/25 16:38:40
- 上 传 者： 上海古朵生物科技有限公司
- 上传时间： 2021/11/25 16:38:40
- 文件大小： 14KB
- 文件类型： docx
- 所属分类： 应用方法
- 下载次数： 3次
- 查看次数： 65
资料简介： 英文名称 Anti-DAZ1 保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Function : RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3＇-UTR of mRNAs ａnd regulating their translation. Promotes germ-cell progression to meiosis ａnd formation of haploid germ cells. Tissue Specificity : Testis-specific. Expression restricted to premeiotic germ cells, particularly in spermatogonia (at protein level). Similarity : Belongs to the RRM DAZ family.
中文名称 无精症缺失基因1抗体
别 名 DAZ 1; DAZ; Deleted in azoospermia 1; Deleted in azoospermia; Deleted in azoospermia protein 1; SPGY; DAZ1_HUMAN.
浓 度 1mg/1ml
规 格 0.2ml/200μg
抗体来源 Rabbit
克隆类型 polyclonal
交叉反应 Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep
产品类型 一抗
研究域 细胞生物 发育生物学 信号转导 干细胞 表观遗传学
蛋白分子量 predicted molecular weight: 83kDa
性 状 Lyophilized or Liquid
免 疫 原 KLH conjugated synthetic peptide derived from Human DAZ1
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
无精症缺失基因1抗体产品介绍 DAZ1 (deleted in azoospermia 1) is an RNA-binding protein that is essential in spermatogenesis. It may regulate translation of mRNAs by binding to the 3＇-UTR.
Subunit : Forms a heterodimer with BOLL ａnd DAZL. Interacts with PUM2, DAZAP1, DAZAP2, DZIP1 ａnd DZIP3.
Subcellular Location : Cylasmic ａnd Nuclear.Note=Predominantly cylasmic. Nuclear at some stages of spermatozoide development. Localizes both to the nuclei ａnd cylasm of spermatozoide differentiation. Nuclear in fetal gonocytes ａnd in spermatogonial nuclei. It then relocates to the cylasm during male meiosis.
DISEASE : Defects in DAZ1 may be a cause of spermatogenic failure Y-linked type 2 (SPGFY2) [MIM:415000]. It is a disorder resulting in the absence (azoospermia) or reduction (oligozoospermia) of sperm in the semen, leading to male infertility. Note=AZFc deletions in the Yq11.23 region including the DAZ genes are the most common known genetic cause of human male infertility.
Contains 9 DAZ-like domains.
Contains 3 RRM (RNA recognition motif) domains.
Database links : UniProtKB/Swiss-Prot: Q9NQZ3.2
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