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人脑微血管内皮细胞HBMEC神经系统细胞
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价格：￥电议
更新日期：2026/9/8 3:56:46
生 产 地：美洲
产品型号：HBMEC
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详细内容
英文名：HBMEC (Human Brain Microvascular Endothelial Cells
主要组成成分，能够限制可溶性物质和细胞等从血液进入大脑。大脑微血管内皮细胞与外周内皮细胞相比具有一些相同特性。如：1）脑微血管内皮细胞存在许多细胞间紧密连接，产生很高的跨内皮阻抗，延迟细胞旁的通量；2）脑微血管内皮细胞缺乏内皮细胞的窗孔结构，其液相物质胞饮水平较低；3）脑微血管内皮细胞具有不对称定位酶和载体介导转运系统，从而产生 “两极分化”的表现型。 与外周内皮细胞相同，大脑微血管内皮细胞表面表达细胞粘附分子，调控白细胞进入大脑。由于微血管内皮细胞的器官特异性，内皮细胞通常取源于疾病研究的相关组织。
人脑微血管内皮细胞(HBMEC)提取于人脑组织，提取纯化之后立即冻存。每管含有细胞数 >5×105 cells/ml，此细胞通过vWF/Factor VIII 和CD31 (P-CAM)免疫荧光染色验证，经测试不含有HIV-1、HBV、HCV、支原体、细菌、酵母和真菌。
储存：液氮
运输：干冰 活细胞
用途：科研
The brain microvascular endothelial cells are the major element of the blood-brain barrier ａnd comprises the primary limitation to passage of substances, both soluble ａnd cellular, from the blood into the brain. Brain microvascular endothelial cells utilize unique features that distinguish themselves from those of peripheral endothelial cells such as 1) numerous intercellular＇tight junctions＇ that display high transendothelial electrical resistance ａnd retard paracellular flux [1]; 2) absence of fenestrae ａnd a reduced level of fluid-phase endocytosis [2] ａnd 3) asymmetrically-localized enzymes ａnd carrier-mediated transport systems that engender a truly ＇polarized＇ phenotype [3]. Like peripheral endothelial cells, however, brain microvacular endothelial cells express cell adhesion molecules on their surface that regulate the extravasation of leukocytes into the brain. In view of the organ specificity of microvascular endothelial cells, endothelial cells should be derived from the tissue involved in the diseases one wishes to study.
HBMEC from ScienCell Research Laboratories are isolated from human brain tissue. HBMEC are cryopreserved immediately after purification ａnd delivered frozen. Each vial contains >5 x 105 cells in 1 ml volume. HBMEC are characterized by immunofluorescent method with antibodies to vWF/Factor VIII ａnd CD31 (P-CAM), by uptake of DiI-Ac-LDL ａnd by the formation of microtublar structure in vitro. HBMEC are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast ａnd fungi. HBMEC are guaranteed to further expand in the conditions specified by ScienCell Research Laboratories.
Reference
[1] Crone, C. ａnd Oleson, S. P. (1992) Electrical resistance of brain microvessel endothelium. Brain Res. 241: 49-55.
[2] Reese, T. S. ａnd Karnovsky, M. J. (1967) Fine structural localization of blood-brain barrier to exogenous peroxidase. J. Cell Biol. 34:9-14.
[3] Vorbrodt, A. W. (1988) Ultrastructural cytochemistry of blood-brain barrier endothelia. Prog. Histochem. Cytochem. 18(3):1-96.
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相关细胞
| HBMEC | 人脑微血管内皮细胞 |
| HBVSMC | 人脑血管平滑肌细胞 |
| HBVAF | 人脑血管外膜成纤维细胞 |
| HBVP | 人脑血管周细胞 |
| HCPEC | 人脉络丛内皮细胞 |
| HCPEpiC | 人脉络丛上皮细胞 |
| HCPF | 人脉络丛成纤维细胞 |
| HMC | 人脑膜细胞 |
| HN | 人神经元细胞 |
| HN | |
| HN | |
| HCGC | 人小脑颗粒细胞 |
| HN-h | 人海马趾神经元 |
| HCN | 人大脑皮层神经元 |
| HN-bs | 人脑干神经元 |
| HOPC | 人少突胶质前体细胞－－贴壁生长 |
| HOPC-os | 人少突胶质前体细胞－－悬浮生长 |
| HO | 人少突胶质细胞 |
| HOPC-f | 人少突胶质前体细胞－－新鲜 |
| HOPC-f40 | |
| HOPC-f80 | |
| HOPC-f20 | |
| HSC | 人雪旺细胞 |
| HPC | 人神经束膜细胞 |
| HA | 人星形胶质细胞 |
| HA | |
| HA | |
| HA-c | 人小脑星形胶质细胞 |
| HA-sp | 人脊髓星形胶质细胞 |
| HA-h | 人海马星形胶质细胞 |
| HA-bs | 人星形胶质细胞－－脑干 |
| HA-mb | 人星形胶质细胞 - 中脑 |
| HRA | 人类视网膜星形胶质细胞 |
| HM | 人小神经胶质细胞 |
