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CD28抗体
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相关标签：CD28抗体
详细内容
产品编号Rs-1297R
英文名称CD28
中文名称CD28抗体
别 名CD 28; CD28 antigen; CD28 molecule; MGC138290; T cell antigen CD28; T cell specific surface glycoprotein; T cell specific surface glycoprotein CD28; Tp44.
说 明 书0.1ml 0.2ml
研究领域细胞生物 免疫学 干细胞 细胞粘附分子 细胞表面分子 淋巴细胞 t-淋巴细胞 b-淋巴细胞
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse,
产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:50-300 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量22kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from mouse CD28
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 ａnd 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMedPubMed
产品介绍background:
Human CD28 antigen is a 44 kDa disulfide linked homodimeric T cell specific surface glycoprotein. It is a cell adhesion molecule of the immunoglobulin superfamily which is constitutively expressed on most peripheral blood T lymphocytes (approximately 95% of CD4+ cells ａnd 50% of CD8+ cells). Mature thymocytes exhibit higher levels of CD28 than the immature cells. Activation of T cells results in enhanced CD28 expression. T cell activation requires two combined signals provided by antigen presenting cells. The first is mediated via the T cell receptor following its interaction with antigenic peptide MHC complexes, ａnd the second is delivered by accessory or costimulating molecules through their counter receptors on T lymphocytes. CD28 bears structural homology to CTLA 4 which is expressed at very low levels on the surface of CD4+ ａnd CD8+ peripheral blood cells only following activation. CD28 is the natural receptor for the B7/BB 1 ligand (CD80) a 55-60 kDa glycoprotein which is expressed on activated B lymphocytes, on dendritic cells ａnd on interferon gamma treated monocytes. The binding of B7 1/BB 1 molecules to CD28 is involved in T lymphocyte activation ａnd in the initiation ａnd maintenance of chronic inflammation.
Function:
Possibly involved in T-cell activation.
Subunit:
Homodimer; disulfide-linked. Interacts with DUSP14. Binds to CD80/B7-1 ａnd CD86/B7-2/B70.
Subcellular Location:
Membrane; Single-pass type I membrane protein.
Similarity:
Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Gene ID:
12487
Database links:
Entrez Gene: 940 Human
Entrez Gene: 12487 Mouse
Omim: 186760 Human
SwissProt: P10747 Human
SwissProt: P31041 Mouse
SwissProt: P42069 Rabbit
Unigene: 591629 Human
Unigene: 255003 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
CD28是免疫球蛋白超家族成员之一 ，为T细胞特异性由二硫键连接的同源二聚体表面糖蛋白，主要分布在外周血淋巴细胞。对迟发型超敏反应以及Tc介导的细胞毒作用都有免疫调节作用。
英文名称CD28
中文名称CD28抗体
别 名CD 28; CD28 antigen; CD28 molecule; MGC138290; T cell antigen CD28; T cell specific surface glycoprotein; T cell specific surface glycoprotein CD28; Tp44.
说 明 书0.1ml 0.2ml
研究领域细胞生物 免疫学 干细胞 细胞粘附分子 细胞表面分子 淋巴细胞 t-淋巴细胞 b-淋巴细胞
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse,
产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:50-300 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量22kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from mouse CD28
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 ａnd 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMedPubMed
产品介绍background:
Human CD28 antigen is a 44 kDa disulfide linked homodimeric T cell specific surface glycoprotein. It is a cell adhesion molecule of the immunoglobulin superfamily which is constitutively expressed on most peripheral blood T lymphocytes (approximately 95% of CD4+ cells ａnd 50% of CD8+ cells). Mature thymocytes exhibit higher levels of CD28 than the immature cells. Activation of T cells results in enhanced CD28 expression. T cell activation requires two combined signals provided by antigen presenting cells. The first is mediated via the T cell receptor following its interaction with antigenic peptide MHC complexes, ａnd the second is delivered by accessory or costimulating molecules through their counter receptors on T lymphocytes. CD28 bears structural homology to CTLA 4 which is expressed at very low levels on the surface of CD4+ ａnd CD8+ peripheral blood cells only following activation. CD28 is the natural receptor for the B7/BB 1 ligand (CD80) a 55-60 kDa glycoprotein which is expressed on activated B lymphocytes, on dendritic cells ａnd on interferon gamma treated monocytes. The binding of B7 1/BB 1 molecules to CD28 is involved in T lymphocyte activation ａnd in the initiation ａnd maintenance of chronic inflammation.
Function:
Possibly involved in T-cell activation.
Subunit:
Homodimer; disulfide-linked. Interacts with DUSP14. Binds to CD80/B7-1 ａnd CD86/B7-2/B70.
Subcellular Location:
Membrane; Single-pass type I membrane protein.
Similarity:
Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Gene ID:
12487
Database links:
Entrez Gene: 940 Human
Entrez Gene: 12487 Mouse
Omim: 186760 Human
SwissProt: P10747 Human
SwissProt: P31041 Mouse
SwissProt: P42069 Rabbit
Unigene: 591629 Human
Unigene: 255003 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
CD28是免疫球蛋白超家族成员之一 ，为T细胞特异性由二硫键连接的同源二聚体表面糖蛋白，主要分布在外周血淋巴细胞。对迟发型超敏反应以及Tc介导的细胞毒作用都有免疫调节作用。
CD28抗体
