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IV型胶原蛋白/4型胶原蛋白/胶原蛋白4抗体
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更新日期：2026/8/7 19:25:58
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相关标签：IV型胶原蛋白/4型胶原蛋白/胶原蛋白4抗体
详细内容
产品编号Rs-0806R
英文名称Collagen IV
中文名称IV型胶原蛋白/4型胶原蛋白/胶原蛋白4抗体
别 名Arresten; Canstatin; COL4A1; HANAC; ICH; POREN1; Collagen Alpha 1(IV) Chain; Collagen IV Alpha 1 Polypeptide; Collagen Of Basement Membrane Alpha 1 Chain; Collagen Of Basement Membrane Alpha 2 Chain; Collagen Type IV Alpha 1; DKFZp686I14213; FLJ22259; collagen alpha-1(IV) chain preproprotein; collagen alpha-1(IV) chain preproprotein; Col4a1 protein; collagen of basement membrane, alpha-1 chain; collagen IV, alpha-1 polypeptide; collagen alpha-1(IV) chain; COL4A1 NC1 domain.
说 明 书0.1ml 0.2ml
研究领域肿瘤 细胞生物
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Dog, Pig, Cow, Horse,
产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量165kDa
细胞定位细胞膜 细胞外基质 分泌型蛋白
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human Collagen alpha-1(IV) chain
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 ａnd 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMedPubMed
产品介绍background:
This gene encodes the major type IV alpha collagen chain of basement membranes. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. [provided by RefSeq, Jul 2008]
Function:
Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a ＇chicken-wire＇ meshwork together with laminins, proteoglycans ａnd entactin/nidogen.
Arresten, comprising the C-terminal NC1 domain, inhibits angiogenesis ａnd tumor formation. The C-terminal half is found to possess the anti-angiogenic activity. Specifically inhibits endothelial cell proliferation, migration ａnd tube formation. Inhibits expression of hypoxia-inducible factor 1alpha ａnd ERK1/2 ａnd p38 MAPK activation. Ligand for alpha1/beta1 integrin.
Subunit:
There are six type IV collagen isoforms, alpha 1(IV)-alpha 6(IV), each of which can form a triple helix structure with 2 other chains to generate type IV collagen network.
Subcellular Location:
Secreted, extracellular space, extracellular matrix, basement membrane.
Tissue Specificity:
Highly expressed in placenta.
Post-translational modifications:
Lysines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in all cases ａnd bind carbohydrates.
Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
Type IV collagens contain numerous cysteine residues which are involved in inter- ａnd intramolecular disulfide bonding. 12 of these, located in the NC1 domain, are conserved in all known type IV collagens.
The trimeric structure of the NC1 domains is stabilized by covalent bonds between Lys ａnd Met residues.
Proteolytic processing produces the C-terminal NC1 peptide, arresten.
DISEASE:
Defects in COL4A1 are a cause of brain small vessel disease with hemorrhage (BSVDH) [MIM:607595]. Brain small vessel diseases underlie 20 to 30 percent of ischemic strokes ａnd a larger proportion of intracerebral hemorrhages. Inheritance is autosomal dominant.
Defects in COL4A1 are the cause of hereditary angiopathy with nephropathy aneurysms ａnd muscle cramps (HANAC) [MIM:611773]. The clinical renal manifestations include hematuria ａnd bilateral large cysts. Histologic analysis revealed complex basement membrane defects in kidney ａnd skin. The systemic angiopathy appears to affect both small vessels ａnd large arteries.
Defects in COL4A1 are a cause of familial porencephaly (POREN1) [MIM:175780]. Porencephaly is a term used for any cavitation or cerebrospinal fluid-filled cyst in the brain. Porencephaly type 1 is usually unilateral ａnd results from focal destructive lesions such as fetal vascular occlusion or birth trauma. Type 2, or schizencephalic porencephaly, is usually symmetric ａnd represents a primary defect or arrest in the development of the cerebral ventricles.
Similarity:
Contains 1 FAD-binding FR-type domain.
Contains 1 ferric oxidoreductase domain.
Gene ID:
1282
Database links:
Entrez Gene: 1282 Human
Omim: 120070 Human
SwissProt: P02462 Human
Unigene: 17441 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
IV型胶原为基底膜的主要成分，主要用于各种良恶性组织(乳腺癌、胃肠道癌等)中基底膜分布情况的研究.IV型胶原是构成基底膜的主要成分。该抗体可特异性识别人的IV型胶原，与人类皮肤、肾、肌肉、脾、淋巴结、胎盘和肺的基底膜呈阳性反应，主要用于各种组织癌症中基底膜情况的研究。
英文名称Collagen IV
中文名称IV型胶原蛋白/4型胶原蛋白/胶原蛋白4抗体
别 名Arresten; Canstatin; COL4A1; HANAC; ICH; POREN1; Collagen Alpha 1(IV) Chain; Collagen IV Alpha 1 Polypeptide; Collagen Of Basement Membrane Alpha 1 Chain; Collagen Of Basement Membrane Alpha 2 Chain; Collagen Type IV Alpha 1; DKFZp686I14213; FLJ22259; collagen alpha-1(IV) chain preproprotein; collagen alpha-1(IV) chain preproprotein; Col4a1 protein; collagen of basement membrane, alpha-1 chain; collagen IV, alpha-1 polypeptide; collagen alpha-1(IV) chain; COL4A1 NC1 domain.
说 明 书0.1ml 0.2ml
研究领域肿瘤 细胞生物
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Dog, Pig, Cow, Horse,
产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量165kDa
细胞定位细胞膜 细胞外基质 分泌型蛋白
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human Collagen alpha-1(IV) chain
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 ａnd 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMedPubMed
产品介绍background:
This gene encodes the major type IV alpha collagen chain of basement membranes. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. [provided by RefSeq, Jul 2008]
Function:
Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a ＇chicken-wire＇ meshwork together with laminins, proteoglycans ａnd entactin/nidogen.
Arresten, comprising the C-terminal NC1 domain, inhibits angiogenesis ａnd tumor formation. The C-terminal half is found to possess the anti-angiogenic activity. Specifically inhibits endothelial cell proliferation, migration ａnd tube formation. Inhibits expression of hypoxia-inducible factor 1alpha ａnd ERK1/2 ａnd p38 MAPK activation. Ligand for alpha1/beta1 integrin.
Subunit:
There are six type IV collagen isoforms, alpha 1(IV)-alpha 6(IV), each of which can form a triple helix structure with 2 other chains to generate type IV collagen network.
Subcellular Location:
Secreted, extracellular space, extracellular matrix, basement membrane.
Tissue Specificity:
Highly expressed in placenta.
Post-translational modifications:
Lysines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in all cases ａnd bind carbohydrates.
Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
Type IV collagens contain numerous cysteine residues which are involved in inter- ａnd intramolecular disulfide bonding. 12 of these, located in the NC1 domain, are conserved in all known type IV collagens.
The trimeric structure of the NC1 domains is stabilized by covalent bonds between Lys ａnd Met residues.
Proteolytic processing produces the C-terminal NC1 peptide, arresten.
DISEASE:
Defects in COL4A1 are a cause of brain small vessel disease with hemorrhage (BSVDH) [MIM:607595]. Brain small vessel diseases underlie 20 to 30 percent of ischemic strokes ａnd a larger proportion of intracerebral hemorrhages. Inheritance is autosomal dominant.
Defects in COL4A1 are the cause of hereditary angiopathy with nephropathy aneurysms ａnd muscle cramps (HANAC) [MIM:611773]. The clinical renal manifestations include hematuria ａnd bilateral large cysts. Histologic analysis revealed complex basement membrane defects in kidney ａnd skin. The systemic angiopathy appears to affect both small vessels ａnd large arteries.
Defects in COL4A1 are a cause of familial porencephaly (POREN1) [MIM:175780]. Porencephaly is a term used for any cavitation or cerebrospinal fluid-filled cyst in the brain. Porencephaly type 1 is usually unilateral ａnd results from focal destructive lesions such as fetal vascular occlusion or birth trauma. Type 2, or schizencephalic porencephaly, is usually symmetric ａnd represents a primary defect or arrest in the development of the cerebral ventricles.
Similarity:
Contains 1 FAD-binding FR-type domain.
Contains 1 ferric oxidoreductase domain.
Gene ID:
1282
Database links:
Entrez Gene: 1282 Human
Omim: 120070 Human
SwissProt: P02462 Human
Unigene: 17441 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
IV型胶原为基底膜的主要成分，主要用于各种良恶性组织(乳腺癌、胃肠道癌等)中基底膜分布情况的研究.IV型胶原是构成基底膜的主要成分。该抗体可特异性识别人的IV型胶原，与人类皮肤、肾、肌肉、脾、淋巴结、胎盘和肺的基底膜呈阳性反应，主要用于各种组织癌症中基底膜情况的研究。
IV型胶原蛋白/4型胶原蛋白/胶原蛋白4抗体
