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c-mer原癌基因酪氨酸激酶抗体
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更新日期：2026/8/7 19:25:58
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相关标签：c-mer原癌基因酪氨酸激酶抗体
详细内容
产品编号Rs-0548R
英文名称MERTK
中文名称c-mer原癌基因酪氨酸激酶抗体
别 名AI323366; MER + SKY; Brt; Bruton agammaglobulinemia tyrosine kinase; BYK; c-mer; c-mer proto-oncogene tyrosine kinase; Dtk; Etk 2; Eyk; FLJ16467; Mer; MER receptor tyrosine kinase; MERTK; MGC133349; Nyk; OTTMUSP00000017810; rdy; Receptor tyrosine kinase; Receptor tyrosine kinase MerTK; Receptor tyrosine tinase gene probably the gene for Rdy; Retinal dystrophy; RP23-30M20.1; RP23-356L21.1; RP38; RSE; Sky; STK kinase; Tif; TYRO3; TYRO3 protein tyrosine kinase 3; TYRO3 protein tyrosine kinase; Tyrosine protein kinase byk; Tyrosine protein kinase DTK; Tyrosine protein kinase RSE; Tyrosine protein kinase SKY.
说 明 书0.1ml 0.2ml
研究领域肿瘤
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat,
产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量108kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human C-Mer
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 ａnd 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMedPubMed
产品介绍background:
The Major Facilitator Superfamily (MFS) is a large ａnd diverse group of secondary transporters that includes uniporters, symporters, ａnd antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, ａnd peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters ａnd antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. Peptide-transporters 2 [solute carrier family 15 (H+/peptide transporter), member 2; SLC15A2; PEPT2 ; Oligopeptide transporter, kidney isoform ; Kidney H(+)/peptide cotransporter; ].
Function:
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, ａnd phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 ａnd induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization ａnd engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 ａnd SOCS3.
Subunit:
Interacts (upon activation) with TNK2; stimulates TNK2 autophosphorylation. Interacts (via N-terminus) with extracellular ligands LGALS3, TUB, TULP1 ａnd GAS6. Interacts with VAV1 in a phosphotyrosine-independent manner.
Subcellular Location:
Membrane; Single-pass type I membrane protein.
Tissue Specificity:
Expressed predominantly in the hematopoietic lineages: macrophages, NK cells, NKT cells, dendritic cells ａnd platelets.
Post-translational modifications:
Autophosphorylated on Tyr⁻⁷44, Tyr⁻⁷48 ａnd Tyr⁻⁷49 in the activation loop allowing full activity. Autophosphorylated on Tyr-867 leading to recruitment of downstream partners of the signaling cascade such as PLCG2.
Similarity:
Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily.
Contains 2 fibronectin type-III domains.
Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 protein kinase domain.
Gene ID:
10461
Database links:
Entrez Gene: 10461 Human
Omim: 604705 Human
SwissProt: Q12866 Human
Unigene: 306178 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
主要用于肿瘤方面的研究
英文名称MERTK
中文名称c-mer原癌基因酪氨酸激酶抗体
别 名AI323366; MER + SKY; Brt; Bruton agammaglobulinemia tyrosine kinase; BYK; c-mer; c-mer proto-oncogene tyrosine kinase; Dtk; Etk 2; Eyk; FLJ16467; Mer; MER receptor tyrosine kinase; MERTK; MGC133349; Nyk; OTTMUSP00000017810; rdy; Receptor tyrosine kinase; Receptor tyrosine kinase MerTK; Receptor tyrosine tinase gene probably the gene for Rdy; Retinal dystrophy; RP23-30M20.1; RP23-356L21.1; RP38; RSE; Sky; STK kinase; Tif; TYRO3; TYRO3 protein tyrosine kinase 3; TYRO3 protein tyrosine kinase; Tyrosine protein kinase byk; Tyrosine protein kinase DTK; Tyrosine protein kinase RSE; Tyrosine protein kinase SKY.
说 明 书0.1ml 0.2ml
研究领域肿瘤
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat,
产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量108kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human C-Mer
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 ａnd 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMedPubMed
产品介绍background:
The Major Facilitator Superfamily (MFS) is a large ａnd diverse group of secondary transporters that includes uniporters, symporters, ａnd antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, ａnd peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters ａnd antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. Peptide-transporters 2 [solute carrier family 15 (H+/peptide transporter), member 2; SLC15A2; PEPT2 ; Oligopeptide transporter, kidney isoform ; Kidney H(+)/peptide cotransporter; ].
Function:
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, ａnd phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 ａnd induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization ａnd engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 ａnd SOCS3.
Subunit:
Interacts (upon activation) with TNK2; stimulates TNK2 autophosphorylation. Interacts (via N-terminus) with extracellular ligands LGALS3, TUB, TULP1 ａnd GAS6. Interacts with VAV1 in a phosphotyrosine-independent manner.
Subcellular Location:
Membrane; Single-pass type I membrane protein.
Tissue Specificity:
Expressed predominantly in the hematopoietic lineages: macrophages, NK cells, NKT cells, dendritic cells ａnd platelets.
Post-translational modifications:
Autophosphorylated on Tyr⁻⁷44, Tyr⁻⁷48 ａnd Tyr⁻⁷49 in the activation loop allowing full activity. Autophosphorylated on Tyr-867 leading to recruitment of downstream partners of the signaling cascade such as PLCG2.
Similarity:
Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily.
Contains 2 fibronectin type-III domains.
Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 protein kinase domain.
Gene ID:
10461
Database links:
Entrez Gene: 10461 Human
Omim: 604705 Human
SwissProt: Q12866 Human
Unigene: 306178 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
主要用于肿瘤方面的研究
c-mer原癌基因酪氨酸激酶抗体
